« Previous Abstract"Flubendiamide, the first phthalic acid diamide insecticide, impairs neuronal calcium signalling in the honey bee's antennae"    Next AbstractGelatin/beta-Cyclodextrin Bio-Nanofibers as respiratory filter media for filtration of aerosols and volatile organic compounds at low air resistance »

J Antibiot (Tokyo)

Title:		Dorrigocins: novel antifungal antibiotics that change the morphology of ras-transformed NIH/3T3 cells to that of normal cells. III. Biological properties and mechanism of action
Author(s):		Kadam S; McAlpine JB;
Address:		"Abbott Laboratories, Abbott Park, Illinois 60064"
Journal Title:		J Antibiot (Tokyo)
Year:		1994
Volume:		47
Issue:		8
Page Number:		875 - 880
DOI:		10.7164/antibiotics.47.875
ISSN/ISBN:		0021-8820 (Print) 0021-8820 (Linking)
Abstract:		"The dorrigocins are unique glutarimide antibiotics which were found to reverse the morphology of ras-transformed NIH/3T3 cells from a transformed phenotype to a normal one. The compounds also inhibited the release of yeast mating pheromone, a-factor. The activity of these compounds was not dependent on inhibition of prenylation or protein synthesis. Dorrigocin A was instead found to inhibit the carboxyl methylation in K-ras transformed cells"
Keywords:		"3T3 Cells/*cytology/*drug effects/metabolism *Alkyl and Aryl Transferases Animals Antifungal Agents/*pharmacology Cell Transformation, Neoplastic/*drug effects/*genetics *Genes, ras Mating Factor Methylation Mice Oncogene Protein p21(ras)/metabolism Pepti;"
Notes:		"MedlineKadam, S McAlpine, J B eng England 1994/08/01 J Antibiot (Tokyo). 1994 Aug; 47(8):875-80. doi: 10.7164/antibiotics.47.875"