| Title: | The LINA cohort: Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy |
| Author(s): | Junge KM; Hornig F; Herberth G; Roder S; Kohajda T; Rolle-Kampczyk U; von Bergen M; Borte M; Simon JC; Heroux D; Denburg JA; Lehmann I; |
| Address: | "Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Environmental Immunology, Germany; McMaster University, Division of Clinical Immunology and Allergy, Hamilton, ON, Canada. Electronic address: kristin.junge@ufz.de. Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Environmental Immunology, Germany. Electronic address: friederike.hoernig@ufz.de. Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Environmental Immunology, Germany. Electronic address: gunda.herberth@ufz.de. Helmholtz Centre for Environmental Research - UFZ, Leipzig, Core Facility Studies, Germany. Electronic address: stefan.roeder@ufz.de. Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Metabolomics, Germany. Electronic address: tibor.kohajda@ufz.de. Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Metabolomics, Germany; Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Proteomics, Germany. Electronic address: ulrike.rolle-kampczyk@ufz.de. Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Metabolomics, Germany; Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Proteomics, Germany; Aalborg University, Department of Biotechnology, Chemistry and Environmental Engineering, Aalborg, Denmark. Electronic address: martin.vonbergen@ufz.de. Children's Hospital, Municipal Hospital 'St. Georg', Leipzig, Germany. Electronic address: Michael.Borte@sanktgeorg.de. University Hospital of Leipzig, Department of Dermatology, Venereology and Allergology, Germany. Electronic address: Jan-Christoph.Simon@medizin.uni-leipzig.de. McMaster University, Division of Clinical Immunology and Allergy, Hamilton, ON, Canada. Electronic address: herouxd@mcmaster.ca. McMaster University, Division of Clinical Immunology and Allergy, Hamilton, ON, Canada. Electronic address: denburg@mcmaster.ca. Helmholtz Centre for Environmental Research - UFZ, Leipzig, Department of Environmental Immunology, Germany. Electronic address: irina.lehmann@ufz.de" |
| DOI: | 10.1016/j.clim.2014.02.013 |
| ISSN/ISBN: | 1521-7035 (Electronic) 1521-6616 (Linking) |
| Abstract: | "RATIONALE: Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. METHODS: In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. RESULTS: Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. CONCLUSIONS: The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment" |
| Keywords: | "Basophils/cytology/drug effects/*immunology Cell Differentiation Cohort Studies Environmental Exposure Eosinophils/cytology/drug effects/*immunology Female Fetal Blood/cytology Fetal Stem Cells/cytology/drug effects/*immunology Humans Infant Infant, Newbo;" |
| Notes: | "MedlineJunge, Kristin M Hornig, Friederike Herberth, Gunda Roder, Stefan Kohajda, Tibor Rolle-Kampczyk, Ulrike von Bergen, Martin Borte, Michael Simon, Jan-Christoph Heroux, Delia Denburg, Judah A Lehmann, Irina eng Research Support, Non-U.S. Gov't 2014/03/13 Clin Immunol. 2014 May-Jun; 152(1-2):68-76. doi: 10.1016/j.clim.2014.02.013. Epub 2014 Mar 4" |
