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Front Physiol

Title:		Insulin Signaling in the Peripheral and Central Nervous System Regulates Female Sexual Receptivity during Starvation in Drosophila
Author(s):		Lebreton S; Carlsson MA; Witzgall P;
Address:		"Division of Chemical Ecology, Department of Plant Protection Biology, Swedish University of Agricultural SciencesAlnarp, Sweden. Department of Zoology, Stockholm UniversityStockholm, Sweden"
Journal Title:		Front Physiol
Year:		2017
Volume:		20170908
Issue:
Page Number:		685 -
DOI:		10.3389/fphys.2017.00685
ISSN/ISBN:		1664-042X (Print) 1664-042X (Electronic) 1664-042X (Linking)
Abstract:		"Many animals adjust their reproductive behavior according to nutritional state and food availability. Drosophila females for instance decrease their sexual receptivity following starvation. Insulin signaling, which regulates many aspects of insect physiology and behavior, also affects reproduction in females. We show that insulin signaling is involved in the starvation-induced reduction in female receptivity. More specifically, females mutant for the insulin-like peptide 5 (dilp5) were less affected by starvation compared to the other dilp mutants and wild-type flies. Knocking-down the insulin receptor, either in all fruitless-positive neurons or a subset of these neurons dedicated to the perception of a male aphrodisiac pheromone, decreased the effect of starvation on female receptivity. Disrupting insulin signaling in some parts of the brain, including the mushroom bodies even abolished the effect of starvation. In addition, we identified fruitless-positive neurons in the dorso-lateral protocerebrum and in the mushroom bodies co-expressing the insulin receptor. Together, our results suggest that the interaction of insulin peptides determines the tuning of female sexual behavior, either by acting on pheromone perception or directly in the central nervous system"
Keywords:		feeding state fruitless insulin mating behavior mushroom bodies;
Notes:		"PubMed-not-MEDLINELebreton, Sebastien Carlsson, Mikael A Witzgall, Peter eng Switzerland 2017/09/26 Front Physiol. 2017 Sep 8; 8:685. doi: 10.3389/fphys.2017.00685. eCollection 2017"