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Blood Adv

Title:		Breath analysis in gastrointestinal graft-versus-host disease after allogeneic hematopoietic cell transplantation
Author(s):		Hamilton BK; Rybicki LA; Grove D; Ferraro C; Starn J; Hodgeman B; Elberson J; Winslow V; Corrigan D; Gerds AT; Hanna R; Kalaycio ME; Sobecks RM; Majhail NS; Dweik RA;
Address:		"Blood and Marrow Transplant Program, Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland, OH. Quantitative Health Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH. Department of Pulmonary and Critical Care Medicine, Respiratory Institute, and. Pediatric Hematology Oncology, Cleveland Clinic, Cleveland, OH"
Journal Title:		Blood Adv
Year:		2019
Volume:		3
Issue:		18
Page Number:		2732 - 2737
DOI:		10.1182/bloodadvances.2019000345
ISSN/ISBN:		2473-9537 (Electronic) 2473-9529 (Print) 2473-9529 (Linking)
Abstract:		"Volatile organic compounds (VOCs) are generated during pathologic processes, and their assessment can be used to diagnose and monitor a variety of diseases. Given the role of the microbiome in graft-versus-host disease (GVHD), we hypothesized that microorganisms producing volatile metabolites may alter VOCs expelled in breath in patients with gastrointestinal (GI) GVHD. In this pilot study, exhaled breath samples were obtained from 19 patients with grade 2 to 4 acute GI GVHD, 10 patients with no GVHD at day 100, and 10 healthy control subjects; the samples were analyzed by using mass spectrometry. Overall, nine (47%) patients had grade 2 GVHD, eight (42%) patients had grade 3 GVHD, and two (11%) patients had grade 4 GVHD; 26% had upper GI, 21% had lower GI, and 53% had both upper and lower GI manifestations. Stepwise canonical discriminant analysis identified 5 VOCs distinguishing patients with and without GI GVHD: 2-propanol, acetaldehyde, dimethyl sulfide, isoprene, and 1-decene (Wilks' Lambda, 0.43; F statistic, 6.08; P = .001). The model correctly classified 89% (17 of 19) and 90% (9 of 10) of patients with and without GI GVHD, respectively. Breath analysis is a feasible and promising noninvasive method to detect acute GI GVHD. Further study of serial breath analysis and the gut microbiome in a larger cohort are ongoing to validate these findings"
Keywords:		Breath Tests/*methods Gastrointestinal Tract/*pathology Graft vs Host Disease/*diagnosis/*etiology Hematopoietic Stem Cell Transplantation/*methods Humans Pilot Projects Transplantation Conditioning/*methods;
Notes:		"MedlineHamilton, Betty K Rybicki, Lisa A Grove, David Ferraro, Christina Starn, Jamie Hodgeman, Brittany Elberson, Jamie Winslow, Victoria Corrigan, Donna Gerds, Aaron T Hanna, Rabi Kalaycio, Matt E Sobecks, Ronald M Majhail, Navneet S Dweik, Raed A eng Research Support, Non-U.S. Gov't 2019/09/19 Blood Adv. 2019 Sep 24; 3(18):2732-2737. doi: 10.1182/bloodadvances.2019000345"