| Title: | Differential exposure and acute health impacts of inhaled solid-fuel emissions from rudimentary and advanced cookstoves in female CD-1 mice |
| Author(s): | Gibbs-Flournoy EA; Gilmour MI; Higuchi M; Jetter J; George I; Copeland L; Harrison R; Moser VC; Dye JA; |
| Address: | "Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA. National Health and Environmental Research Laboratory (NHEERL), Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. National Risk Management Research Laboratory (NRMRL), Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. National Health and Environmental Research Laboratory (NHEERL), Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA. Electronic address: dye.janice@epa.gov" |
| DOI: | 10.1016/j.envres.2017.10.043 |
| ISSN/ISBN: | 1096-0953 (Electronic) 0013-9351 (Print) 0013-9351 (Linking) |
| Abstract: | "BACKGROUND: There is an urgent need to provide access to cleaner end user energy technologies for the nearly 40% of the world's population who currently depend on rudimentary cooking and heating systems. Advanced cookstoves (CS) are designed to cut emissions and solid-fuel consumption, thus reducing adverse human health and environmental impacts. STUDY PREMISE: We hypothesized that, compared to a traditional (Tier 0) three-stone (3-S) fire, acute inhalation of solid-fuel emissions from advanced natural-draft (ND; Tier 2) or forced-draft (FD; Tier 3) stoves would reduce exposure biomarkers and lessen pulmonary and innate immune system health effects in exposed mice. RESULTS: Across two simulated cooking cycles (duration ~ 3h), emitted particulate mass concentrations were reduced 80% and 62% by FD and ND stoves, respectively, compared to the 3-S fire; with corresponding decreases in particles visible within murine alveolar macrophages. Emitted carbon monoxide was reduced ~ 90% and ~ 60%, respectively. Only 3-S-fire-exposed mice had increased carboxyhemoglobin levels. Emitted volatile organic compounds were FD << 3-S-fire |
| Keywords: | "*Air Pollution, Indoor/adverse effects Animals Carbon Monoxide *Cooking Female *Fires *Household Articles Humans *Inhalation Exposure Mice Particulate Matter Cookstoves Incomplete combustion Lung injury Oxidative stress Phagocytosis;" |
| Notes: | "MedlineGibbs-Flournoy, Eugene A Gilmour, M Ian Higuchi, Mark Jetter, James George, Ingrid Copeland, Lisa Harrison, Randy Moser, Virginia C Dye, Janice A eng EPA999999/Intramural EPA/ Netherlands 2017/11/04 Environ Res. 2018 Feb; 161:35-48. doi: 10.1016/j.envres.2017.10.043. Epub 2017 Nov 1" |
