« Previous AbstractIn vitro biocompatibility of titanium oxide for prosthetic devices nanostructured by low pressure metal-organic chemical vapor deposition    Next Abstract"Identification of sex pheromone components of a New Zealand geometrid moth, the common forest looper Pseudocoremia suavis, reveals a possible species complex" »

Biol Neonate

Title:		Diet composition modifies embryotoxic effects induced by experimental diabetes in rats
Author(s):		Giavini E; Broccia ML; Prati M; Domenico Roversi G;
Address:		"Department of Biology, University of Milan, Italy"
Journal Title:		Biol Neonate
Year:		1991
Volume:		59
Issue:		5
Page Number:		278 - 286
DOI:		10.1159/000243361
ISSN/ISBN:		0006-3126 (Print) 0006-3126 (Linking)
Abstract:		"Despite improvements in prenatal care, the incidence of congenital malformations in diabetic pregnancies is still 3-4 times higher than in normal pregnancies. These defects could be attributed to alterations of intrauterine environment due to disorder of the maternal metabolism. If this were true, the quality of food could play a role in diabetes-induced embryotoxicity. To check this hypothesis, female CD rats were made diabetic by injecting intravenously 50 mg/kg of streptozotocin 2 weeks before mating. From the first day of pregnancy they were divided into three groups and maintained on the following diets: (1) standard diet (Italiana Mangimi); (2) purified high protein diet (protein 55%, carbohydrates 25.5%, fat 7.5%, fiber 4.5%, ash 7.5%); (3) purified normoprotein diet (protein 19%, carbohydrates 62.5%, fat 7.5%, fiber 4%, ash 7%). Nondiabetic pregnant females fed with standard diet served as negative control. No significant differences were observed in blood glucose levels among the groups (range 410-500 mg/dl). The group fed on normoprotein diet showed at term of pregnancy: (1) higher rate of resorptions; (2) lower fetal weight; (3) higher frequency of major malformations than the groups fed standard and hyperproteic diets. Although we are not able at this time to discriminate between a protective effect of a diet with a high protein content and a disruptive effect of a diet containing high quantity of carbohydrates, the results of this trial support the hypothesis of a fuel-mediated teratogenesis in diabetic pregnancy"
Keywords:		"Animals Congenital Abnormalities/*embryology/etiology/physiopathology Diabetes Mellitus, Experimental/*embryology/etiology/physiopathology Diet/*adverse effects Dietary Proteins/administration & dosage Embryo Loss *Embryonic and Fetal Development Female P;"
Notes:		"MedlineGiavini, E Broccia, M L Prati, M Domenico Roversi, G eng Switzerland 1991/01/01 Biol Neonate. 1991; 59(5):278-86. doi: 10.1159/000243361"