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Science

Title:		Drosophila life span and physiology are modulated by sexual perception and reward
Author(s):		Gendron CM; Kuo TH; Harvanek ZM; Chung BY; Yew JY; Dierick HA; Pletcher SD;
Address:		"Department of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, MI 48109, USA"
Journal Title:		Science
Year:		2014
Volume:		20131129
Issue:		6170
Page Number:		544 - 548
DOI:		10.1126/science.1243339
ISSN/ISBN:		1095-9203 (Electronic) 0036-8075 (Print) 0036-8075 (Linking)
Abstract:		"Sensory perception can modulate aging and physiology across taxa. We found that perception of female sexual pheromones through a specific gustatory receptor expressed in a subset of foreleg neurons in male fruit flies, Drosophila melanogaster, rapidly and reversibly decreases fat stores, reduces resistance to starvation, and limits life span. Neurons that express the reward-mediating neuropeptide F are also required for pheromone effects. High-throughput whole-genome RNA sequencing experiments revealed a set of molecular processes that were affected by the activity of the longevity circuit, thereby identifying new candidate cell-nonautonomous aging mechanisms. Mating reversed the effects of pheromone perception; therefore, life span may be modulated through the integrated action of sensory and reward circuits, and healthy aging may be compromised when the expectations defined by sensory perception are discordant with ensuing experience"
Keywords:		"Animals Drosophila Proteins/physiology Drosophila melanogaster/genetics/*physiology Female Ion Channels/physiology Longevity/genetics/*physiology Male Neurons/physiology Neuropeptides/physiology Pheromones/*physiology *Reward Sequence Analysis, RNA Sexual;"
Notes:		"MedlineGendron, Christi M Kuo, Tsung-Han Harvanek, Zachary M Chung, Brian Y Yew, Joanne Y Dierick, Herman A Pletcher, Scott D eng T32GM008322/GM/NIGMS NIH HHS/ R01 AG030593/AG/NIA NIH HHS/ R01 AG043972/AG/NIA NIH HHS/ F32AG042253/AG/NIA NIH HHS/ TR01AG043972/AG/NIA NIH HHS/ P30 DK020572/DK/NIDDK NIH HHS/ P30-AG-013283/AG/NIA NIH HHS/ R01AG023166/AG/NIA NIH HHS/ T32GM007863/GM/NIGMS NIH HHS/ T32 AG000114/AG/NIA NIH HHS/ R01 GM102279/GM/NIGMS NIH HHS/ T32AG000114/AG/NIA NIH HHS/ F32 AG042253/AG/NIA NIH HHS/ R01AG030593/AG/NIA NIH HHS/ T32 GM007863/GM/NIGMS NIH HHS/ T32 GM008322/GM/NIGMS NIH HHS/ R01 AG023166/AG/NIA NIH HHS/ P30 AG013283/AG/NIA NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2013/12/03 Science. 2014 Jan 31; 343(6170):544-8. doi: 10.1126/science.1243339. Epub 2013 Nov 29"