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J Zhejiang Univ Sci B

Title:		Analysis of volatile organic compounds in exhaled breath after radiotherapy
Author(s):		Ge D; Zou X; Chu Y; Zhou J; Xu W; Liu Y; Zhang Q; Lu Y; Xia L; Li A; Huang C; Wang P; Shen C; Chu Y;
Address:		"Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China. University of Science and Technology of China, Hefei 230026, China. Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China. xzou@cmpt.ac.cn. Department of Laboratory Medicine, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China. Department of Laboratory Medicine, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China. xzou@cmpt.ac.cn, 61775618@qq.com"
Journal Title:		J Zhejiang Univ Sci B
Year:		2022
Volume:		23
Issue:		2
Page Number:		153 - 157
DOI:		10.1631/jzus.B2100447
ISSN/ISBN:		1862-1783 (Electronic) 1673-1581 (Print) 1673-1581 (Linking)
Abstract:		"Radiotherapy uses high-energy X-rays or other particles to destroy cancer cells and medical practitioners have used this approach extensively for cancer treatment (Hachadorian et al., 2020). However, it is accompanied by risks because it seriously harms normal cells while killing cancer cells. The side effects can lower cancer patients' quality of life and are very unpredictable due to individual differences (Bentzen, 2006). Therefore, it is essential to assess a patient's body damage after radiotherapy to formulate an individualized recovery treatment plan. Exhaled volatile organic compounds (VOCs) can be changed by radiotherapy and thus used for medical diagnosis (Vaks et al., 2012). During treatment, high-energy X-rays can induce apoptosis; meanwhile, cell membranes are damaged due to lipid peroxidation, converting unsaturated fatty acids into volatile metabolites (Losada-Barreiro and Bravo-Diaz, 2017). At the same time, radiotherapy oxidizes water, resulting in reactive oxygen species (ROS) that can increase the epithelial permeability of pulmonary alveoli, enabling the respiratory system to exhale volatile metabolites (Davidovich et al., 2013; Popa et al., 2020). These exhaled VOCs can be used to monitor body damage caused by radiotherapy"
Keywords:		Breath Tests/methods Exhalation Humans Quality of Life Respiratory System/chemistry *Volatile Organic Compounds/analysis;
Notes:		"MedlineGe, Dianlong Zou, Xue Chu, Yajing Zhou, Jijuan Xu, Wei Liu, Yue Zhang, Qiangling Lu, Yan Xia, Lei Li, Aiyue Huang, Chaoqun Wang, Pei Shen, Chengyin Chu, Yannan eng 21876176, 21777163, 21705152 and 22076190/the National Natural Science Foundation of China/ 2019432/the Youth Innovation Promotion Association, Chinese Academy of Sciences/ YZJJZX202009/the Presidential Foundation of Hefei Institute of Physical Sciences of Chinese Academy of Sciences/ Y9BS0C1291/the Functional Development Program of Instrument and Equipment in Chinese Academy of Sciences/ 202104d07020003/the Anhui Provincial Key R&D Program/ LHJJ2020006/the Joint Fund of the Second Affiliated Hospital of Anhui Medical University and the Center of Medical Physics and Technology of Hefei Institute of Physical Sciences of the Chinese Academy of Sciences/ China 2022/02/22 J Zhejiang Univ Sci B. 2022 Feb 15; 23(2):153-157. doi: 10.1631/jzus.B2100447"