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Phytomedicine

Title:		Essential oils and its bioactive compounds modulating cytokines: A systematic review on anti-asthmatic and immunomodulatory properties
Author(s):		Gandhi GR; Vasconcelos ABS; Haran GH; Calisto V; Jothi G; Quintans JSS; Cuevas LE; Narain N; Junior LJQ; Cipolotti R; Gurgel RQ;
Address:		"Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil; Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Sao Cristovao, 49.100-000 Sergipe, Brazil. Electronic address: egarajiv@hotmail.com. Department of Physiology, Federal University of Sergipe, Sao Cristovao, 49.100-000 Sergipe, Brazil. Department of Biochemistry, Srimad Andavan Arts and Science College (Autonomous), Tiruchirappalli, 620005 Tamil Nadu, India. Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil. Laboratory of Neuroscience and Pharmacological Assays (LANEF), Department of Physiology, Federal University of Sergipe, Sao Cristovao, 49.100-000 Sergipe, Brazil. Liverpool School of Tropical Medicine, Pembroke Place Liverpool, Liverpool, UK. Laboratory of Flavor and Chromatographic Analysis, Federal University of Sergipe, Sao Cristovao, Aracaju, Sergipe 49.100-000, Brazil. Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Claudio Batista, s/n, Cidade Nova, Aracaju, 49.100-000 Sergipe, Brazil. Electronic address: ricardoqgurgel@gmail.com"
Journal Title:		Phytomedicine
Year:		2020
Volume:		20190131
Issue:
Page Number:		152854 -
DOI:		10.1016/j.phymed.2019.152854
ISSN/ISBN:		1618-095X (Electronic) 0944-7113 (Linking)
Abstract:		"BACKGROUND: Asthma, the main inflammatory chronic condition affecting the respiratory system, is characterized by hyperresponsiveness and reversible airway obstruction, recruitment of inflammatory cells and excessive production of mucus. Cytokines as biochemical messengers of immune cells, play an important role in the regulation of allergic inflammatory and infectious airway processes. Essential oils of plant origin are complex mixtures of volatile and semi volatile organic compounds that determine the specific aroma of plants and are categorized by their biological activities. PURPOSE: We reviewed whether essential oils and their bioactive compounds of plant origin could modulate cytokines' immune responses and improve asthma therapy in experimental systems in vitro and in vivo. METHODS: Electronic and manual search of articles in English available from inception up to November 2018 reporting the immunomodulatory activity of essential oils and their bioactive compounds for the management of asthma. We used PubMed, EMBASE, Scopus and Web of Science. Publications reporting preclinical experiments where cytokines were examined to evaluate the consequence of anti-asthmatic therapy were included. RESULTS: 914 publications were identified and 13 were included in the systematic review. Four articles described the role of essential oils and their bioactive compounds on bronchial asthma using cell lines; nine in vivo studies evaluated the anti-inflammatory efficacy and immunomodulating effects of essential oil and their secondary metabolites on cytokines production and inflammatory responses. The most important immunopharmacological mechanisms reported were the regulation of cytokine production, inhibition of reactive oxygen species accumulation, inactivation of eosinophil migration and remodeling of the airways and lung tissue, modulation of FOXP3 gene expression, regulation of inflammatory cells in the airways and decreasing inflammatory mediator expression levels. CONCLUSION: Plant derived essential oils and related active compounds have potential therapeutic activity for the treatment of asthma by modulating the release of pro-inflammatory (TNF-alpha, IL-1beta, IL-8), Th17 (IL-17), anti-inflammatory (IL-10), Th1 (IFN-gamma, IL-2, IL-12) and Th2 (IL-4, IL-5, IL-6, IL-13) cytokines and the suppression of inflammatory cell accumulation"
Keywords:		Animals Anti-Asthmatic Agents/chemistry/*pharmacology Anti-Inflammatory Agents/chemistry/pharmacology Asthma/drug therapy Cytokines/*metabolism Humans Hypersensitivity/drug therapy Immunologic Factors/chemistry/*pharmacology Interleukin-17/metabolism Lung;neuroscience;
Notes:		"MedlineGandhi, Gopalsamy Rajiv Vasconcelos, Alan Bruno Silva Haran, Govindasamy Hari Calisto, Valdete Kaliane da Silva Jothi, Gnanasekaran Quintans, Jullyana de Souza Siqueira Cuevas, Luis Eduardo Narain, Narendra Junior, Lucindo Jose Quintans Cipolotti, Rosana Gurgel, Ricardo Queiroz eng Systematic Review Germany 2019/05/01 Phytomedicine. 2020 Jul 15; 73:152854. doi: 10.1016/j.phymed.2019.152854. Epub 2019 Jan 31"