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Antonie Van Leeuwenhoek

Title:		Molecular cloning of Saccharomyces cerevisiae MGC1/YDR473c gene which is essential for cell growth
Author(s):		Fujimura H;
Address:		"Nippon Organon, c/o Sankyo Factory, Tokyo, Japan. Fujimura.Hiroaki@organon.co.jp"
Journal Title:		Antonie Van Leeuwenhoek
Year:		2000
Volume:		77
Issue:		1
Page Number:		65 - 69
DOI:		10.1023/a:1002007126006
ISSN/ISBN:		0003-6072 (Print) 0003-6072 (Linking)
Abstract:		"Saccharomyces cerevisiae haploid cells undergo morphological changes in response to mating pheromones, a- and alpha-factors, during sexual conjugation. As a first step to elucidate the mechanism, I had previously identified the mgc1 mutation which affected the morphogenesis induced by mating pheromones. The mutation had been designated mgc1 for morphogenesis control. In the present study I cloned the MGC1 gene. Sequencing analysis indicates that the MGC1 gene corresponds to the YDR473c gene. The MGC1 gene was shown to be essential for cell growth and required for the transition from the G1 to S phase of cell cycle. Protein-protein interaction of Mgc1 protein was shown by using yeast two-hybrid system. Mgc1 protein was also proposed to be localized in the nucleus in yeast cells"
Keywords:		"Cell Division/genetics Chemotactic Factors Cloning, Molecular Fungal Proteins/*genetics/metabolism Morphogenesis *Nuclear Proteins *Ribonucleoprotein, U4-U6 Small Nuclear Saccharomyces cerevisiae/cytology/*genetics/growth & development *Saccharomyces cere;"
Notes:		"MedlineFujimura, H eng Netherlands 2000/03/04 Antonie Van Leeuwenhoek. 2000 Jan; 77(1):65-9. doi: 10.1023/a:1002007126006"