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Chemosphere

Title:		Non-target screening and human risk assessment for adult and child populations of semi-volatile organic compounds in residential indoor dust in Spain
Author(s):		Fuentes-Ferragud E; Miralles P; Lopez A; Ibanez M; Coscolla C;
Address:		"Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO-Public Health), Av. Catalunya 21, 46020, Valencia, Spain; Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Av. Sos Baynat S/N, 12071, Castello de la Plana, Spain. Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO-Public Health), Av. Catalunya 21, 46020, Valencia, Spain. Electronic address: pablo.miralles@fisabio.es. Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO-Public Health), Av. Catalunya 21, 46020, Valencia, Spain. Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Av. Sos Baynat S/N, 12071, Castello de la Plana, Spain"
Journal Title:		Chemosphere
Year:		2023
Volume:		20230818
Issue:
Page Number:		139879 -
DOI:		10.1016/j.chemosphere.2023.139879
ISSN/ISBN:		1879-1298 (Electronic) 0045-6535 (Linking)
Abstract:		"In this work, an analytical strategy based on non-target screening of semi-volatile organic compounds and subsequent risk assessment for adult and child populations has been conducted for the first time in household indoor dust samples in Spain. The methodology was based on a microwave-assisted extraction followed by gas chromatography coupled to high resolution mass spectrometry determination, using a hybrid quadrupole-orbitrap analyzer. The procedure was applied to 19 residential indoor dust samples, collected in different Spanish regions (namely Galicia, La Rioja, Catalunya, the Balearic Islands, and the Valencian Region). From the generated data, 4067 features were obtained, of which 474 compounds were tentatively identified with a high level of identification confidence (probable structure by library spectrum match or confirmed by reference standard), using a restrictive set of identification criteria. Most of the identified chemicals were natural products, metabolites, additives, and substances with industrial applications in the field of foods, cosmetics, pharmaceuticals, pesticides, and plastics. Finally, risk assessment was carried out by applying the threshold of toxicological concern approach, showing that risk to adult and child populations associated with the presence of the identified substances in the indoor dust was not expected, although the existence of indoor environments with conditions of potential risk cannot be discarded under a worst-case scenario approach"
Keywords:		Humans Adult Child Spain *Volatile Organic Compounds Gas Chromatography-Mass Spectrometry *Biological Products Dust Risk Assessment Gas chromatography High resolution mass spectrometry Indoor dust Non-target screening Semi-volatile organic compounds;
Notes:		"MedlineFuentes-Ferragud, Esther Miralles, Pablo Lopez, Antonio Ibanez, Maria Coscolla, Clara eng England 2023/08/21 Chemosphere. 2023 Nov; 340:139879. doi: 10.1016/j.chemosphere.2023.139879. Epub 2023 Aug 18"