| Title: | Innovations in phenotyping of mouse models in the German Mouse Clinic |
| Author(s): | Fuchs H; Gailus-Durner V; Neschen S; Adler T; Afonso LC; Aguilar-Pimentel JA; Becker L; Bohla A; Calzada-Wack J; Cohrs C; Dewert A; Fridrich B; Garrett L; Glasl L; Gotz A; Hans W; Holter SM; Horsch M; Hurt A; Janas E; Janik D; Kahle M; Kistler M; Klein-Rodewald T; Lengger C; Ludwig T; Maier H; Marschall S; Micklich K; Moller G; Naton B; Prehn C; Puk O; Racz I; Rass M; Rathkolb B; Rozman J; Scheerer M; Schiller E; Schrewe A; Steinkamp R; Stoger C; Sun M; Szymczak W; Treise I; Vargas Panesso IL; Vernaleken AM; Willershauser M; Wolff-Muscate A; Zeh R; Adamski J; Beckers J; Bekeredjian R; Busch DH; Eickelberg O; Favor J; Graw J; Hofler H; Hoschen C; Katus H; Klingenspor M; Klopstock T; Neff F; Ollert M; Schulz H; Stoger T; Wolf E; Wurst W; Yildirim AO; Zimmer A; Hrabe de Angelis M; |
| Address: | "German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health (GmbH), Ingolstadter Landstrasse 1, 85764 Neuherberg/Munich, Germany" |
| DOI: | 10.1007/s00335-012-9415-1 |
| ISSN/ISBN: | 1432-1777 (Electronic) 0938-8990 (Print) 0938-8990 (Linking) |
| Abstract: | "Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ('bottom-up projects') and as a partner and driver in international large-scale biology projects ('top-down projects'). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs)" |
| Keywords: | "Animals Germany Mice *Models, Animal Phenotype;" |
| Notes: | "MedlineFuchs, Helmut Gailus-Durner, Valerie Neschen, Susanne Adler, Thure Afonso, Luciana Caminha Aguilar-Pimentel, Juan Antonio Becker, Lore Bohla, Alexander Calzada-Wack, Julia Cohrs, Christian Dewert, Anna Fridrich, Barbara Garrett, Lillian Glasl, Lisa Gotz, Alexander Hans, Wolfgang Holter, Sabine M Horsch, Marion Hurt, Anja Janas, Eva Janik, Dirk Kahle, Melanie Kistler, Martin Klein-Rodewald, Tanja Lengger, Christoph Ludwig, Tonia Maier, Holger Marschall, Susan Micklich, Kateryna Moller, Gabriele Naton, Beatrix Prehn, Cornelia Puk, Oliver Racz, Ildiko Rass, Michael Rathkolb, Birgit Rozman, Jan Scheerer, Markus Schiller, Evelyn Schrewe, Anja Steinkamp, Ralph Stoger, Claudia Sun, Minxuan Szymczak, Wilfried Treise, Irina Vargas Panesso, Ingrid Liliana Vernaleken, Alexandra M Willershauser, Monja Wolff-Muscate, Annemarie Zeh, Ramona Adamski, Jerzy Beckers, Johannes Bekeredjian, Raffi Busch, Dirk H Eickelberg, Oliver Favor, Jack Graw, Jochen Hofler, Heinz Hoschen, Christoph Katus, Hugo Klingenspor, Martin Klopstock, Thomas Neff, Frauke Ollert, Markus Schulz, Holger Stoger, Tobias Wolf, Eckhard Wurst, Wolfgang Yildirim, Ali Onder Zimmer, Andreas Hrabe de Angelis, Martin eng Research Support, Non-U.S. Gov't 2012/08/29 Mamm Genome. 2012 Oct; 23(9-10):611-22. doi: 10.1007/s00335-012-9415-1. Epub 2012 Aug 29" |
