| Title: | Exhaled Aldehydes as Biomarkers for Lung Diseases: A Narrative Review |
| Author(s): | Floss MA; Fink T; Maurer F; Volk T; Kreuer S; Muller-Wirtz LM; |
| Address: | "CBR-Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center, 66421 Homburg, Germany. Outcomes Research Consortium, Cleveland, OH 44195, USA" |
| DOI: | 10.3390/molecules27165258 |
| ISSN/ISBN: | 1420-3049 (Electronic) 1420-3049 (Linking) |
| Abstract: | "Breath analysis provides great potential as a fast and non-invasive diagnostic tool for several diseases. Straight-chain aliphatic aldehydes were repeatedly detected in the breath of patients suffering from lung diseases using a variety of methods, such as mass spectrometry, ion mobility spectrometry, or electro-chemical sensors. Several studies found increased concentrations of exhaled aldehydes in patients suffering from lung cancer, inflammatory and infectious lung diseases, and mechanical lung injury. This article reviews the origin of exhaled straight-chain aliphatic aldehydes, available detection methods, and studies that found increased aldehyde exhalation in lung diseases" |
| Keywords: | Aldehydes/analysis Biomarkers/analysis Breath Tests/methods Exhalation Humans *Lung Neoplasms/diagnosis *Volatile Organic Compounds aldehydes biomarker lipid peroxidation oxidative stress volatile organic compounds; |
| Notes: | "MedlineFloss, Maximilian Alexander Fink, Tobias Maurer, Felix Volk, Thomas Kreuer, Sascha Muller-Wirtz, Lukas Martin eng Review Switzerland 2022/08/27 Molecules. 2022 Aug 17; 27(16):5258. doi: 10.3390/molecules27165258" |
