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Sensors (Basel)

Title:		A Barcoded Polymer-Based Cross-Reactive Spectroscopic Sensor Array for Organic Volatiles
Author(s):		Fitzgerald JE; Shen J; Fenniri H;
Address:		"Department of Bioengineering, Northeastern University, Boston, MA 02115, USA. School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325000, China. Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, China. Department of Bioengineering, Northeastern University, Boston, MA 02115, USA. h.fenniri@northeastern.edu. Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA. h.fenniri@northeastern.edu. Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA 02115, USA. h.fenniri@northeastern.edu"
Journal Title:		Sensors (Basel)
Year:		2019
Volume:		20190824
Issue:		17
Page Number:		-
DOI:		10.3390/s19173683
ISSN/ISBN:		1424-8220 (Electronic) 1424-8220 (Linking)
Abstract:		"The development of cross-reactive sensor arrays for volatile organics (electronic noses, e-noses) is an active area of research. In this manuscript, we present a new format for barcoded polymer sensor arrays based on porous polymer beads. An array of nine self-encoded polymers was analyzed by Raman spectroscopy before and after exposure to a series of volatile organic compounds, and the changes in the vibrational fingerprints of their polymers was recorded before and after exposure. Our results show that the spectroscopic changes experienced by the porous spectroscopically encoded beads after exposure to an analyte can be used to identify and classify the target analytes. To expedite this analysis, analyte-specific changes induced in the sensor arrays were transformed into a response pattern using multivariate data analysis. These studies established the barcoded bead array format as a potentially effective sensing element in e-nose devices. Devices such as these have the potential to advance personalized medicine, providing a platform for non-invasive, real-time volatile metabolite detection"
Keywords:		Raman spectroscopy barcoded polymers electronic nose sensor arrays;
Notes:		"PubMed-not-MEDLINEFitzgerald, Jessica E Shen, Jianliang Fenniri, Hicham eng Switzerland 2019/08/28 Sensors (Basel). 2019 Aug 24; 19(17):3683. doi: 10.3390/s19173683"