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Proc Natl Acad Sci U S A

Title:		Memory of recent oxygen experience switches pheromone valence in Caenorhabditis elegans
Author(s):		Fenk LA; de Bono M;
Address:		"Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom. Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, United Kingdom debono@mrc-lmb.cam.ac.uk"
Journal Title:		Proc Natl Acad Sci U S A
Year:		2017
Volume:		20170403
Issue:		16
Page Number:		4195 - 4200
DOI:		10.1073/pnas.1618934114
ISSN/ISBN:		1091-6490 (Electronic) 0027-8424 (Print) 0027-8424 (Linking)
Abstract:		"Animals adjust their behavioral priorities according to momentary needs and prior experience. We show that Caenorhabditis elegans changes how it processes sensory information according to the oxygen environment it experienced recently. C. elegans acclimated to 7% O(2) are aroused by CO(2) and repelled by pheromones that attract animals acclimated to 21% O(2) This behavioral plasticity arises from prolonged activity differences in a circuit that continuously signals O(2) levels. A sustained change in the activity of O(2)-sensing neurons reprograms the properties of their postsynaptic partners, the RMG hub interneurons. RMG is gap-junctionally coupled to the ASK and ADL pheromone sensors that respectively drive pheromone attraction and repulsion. Prior O(2) experience has opposite effects on the pheromone responsiveness of these neurons. These circuit changes provide a physiological correlate of altered pheromone valence. Our results suggest C. elegans stores a memory of recent O(2) experience in the RMG circuit and illustrate how a circuit is flexibly sculpted to guide behavioral decisions in a context-dependent manner"
Keywords:		"Animals Animals, Genetically Modified/genetics/growth & development/*metabolism Caenorhabditis elegans/drug effects/growth & development/*metabolism Caenorhabditis elegans Proteins/*metabolism Memory/*physiology Neurons/cytology/*drug effects/physiology O;"
Notes:		"MedlineFenk, Lorenz A de Bono, Mario eng 269058/ERC_/European Research Council/International MRC_/Medical Research Council/United Kingdom Research Support, Non-U.S. Gov't 2017/04/05 Proc Natl Acad Sci U S A. 2017 Apr 18; 114(16):4195-4200. doi: 10.1073/pnas.1618934114. Epub 2017 Apr 3"