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Molecules

Title:		A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth
Author(s):		Fatima S; Farzeen I; Ashraf A; Aslam B; Ijaz MU; Hayat S; Sarfraz MH; Zafar S; Zafar N; Unuofin JO; Lebelo SL; Muzammil S;
Address:		"Department of Zoology, Government College University, Faisalabad 38000, Pakistan. Institute of Microbiology, Government College University, Faisalabad 38000, Pakistan. Department of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad 38040, Pakistan. Department of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, Private Bag X06, Florida 1710, South Africa"
Journal Title:		Molecules
Year:		2023
Volume:		20230414
Issue:		8
Page Number:		-
DOI:		10.3390/molecules28083469
ISSN/ISBN:		1420-3049 (Electronic) 1420-3049 (Linking)
Abstract:		"As is well known, plant products have been increasingly utilized in the pharmaceutical industry in recent years. By combining conventional techniques and modern methodology, the future of phytomedicines appears promising. Pogostemon Cablin (patchouli) is an important herb used frequently in the fragrance industries and has various therapeutic benefits. Traditional medicine has long used the essential oil of patchouli (P. cablin) as a flavoring agent recognized by the FDA. This is a gold mine for battling pathogens in China and India. In recent years, this plant has seen a significant surge in use, and approximately 90% of the world's patchouli oil is produced by Indonesia. In traditional therapies, it is used for the treatment of colds, fever, vomiting, headaches, and stomachaches. Patchouli oil is used in curing many diseases and in aromatherapy to treat depression and stress, soothe nerves, regulate appetite, and enhance sexual attraction. More than 140 substances, including alcohols, terpenoids, flavonoids, organic acids, phytosterols, lignins, aldehydes, alkaloids, and glycosides, have been identified in P. cablin. Pachypodol (C18H16O7) is an important bioactive compound found in P. cablin. Pachypodol (C18H16O7) and many other biologically essential chemicals have been separated from the leaves of P. cablin and many other medicinally significant plants using repeated column chromatography on silica gel. Pachypodol's bioactive potential has been shown by a variety of assays and methodologies. It has been found to have a number of biological activities, including anti-inflammatory, antioxidant, anti-mutagenic, antimicrobial, antidepressant, anticancer, antiemetic, antiviral, and cytotoxic ones. The current study, which is based on the currently available scientific literature, intends to close the knowledge gap regarding the pharmacological effects of patchouli essential oil and pachypodol, a key bioactive molecule found in this plant"
Keywords:		"*Pogostemon *Plants, Medicinal Quercetin *Oils, Volatile/pharmacology/chemistry Pogostemon cablin anti-cancerous anti-inflammatory anti-microbial essential oil flavonoids pachypodol;"
Notes:		"MedlineFatima, Sehrish Farzeen, Iqra Ashraf, Asma Aslam, Bilal Ijaz, Muhammad Umar Hayat, Sumreen Sarfraz, Muhammad Hassan Zafar, Saima Zafar, Nimrah Unuofin, Jeremiah Oshiomame Lebelo, Sogolo Lucky Muzammil, Saima eng Review Switzerland 2023/04/28 Molecules. 2023 Apr 14; 28(8):3469. doi: 10.3390/molecules28083469"