| Title: | Neuroligin 1 expression is linked to plasticity of behavioral and neuronal responses to sex pheromone in the male moth Agrotis ipsilon |
| Author(s): | Durand N; Aguilar P; Demondion E; Bourgeois T; Bozzolan F; Debernard S; |
| Address: | "FRE CNRS 3498, Ecologie et Dynamique des Systemes Anthropises, Universite de Picardie, Jules Verne, 80039 Amiens, France. Institute of Biology, Complutense University of Madrid, Pozuelo de Alarcon, 28223 Madrid, Spain. Sorbonne Universite, INRA, CNRS, UPEC, IRD, Univ. P7, Institute of Ecology and Environmental Sciences of Paris, 78026 Versailles, France. Sorbonne Universite, INRA, CNRS, UPEC, IRD, Univ. P7, Institute of Ecology and Environmental Sciences of Paris, 75005 Paris, France" |
| ISSN/ISBN: | 1477-9145 (Electronic) 0022-0949 (Linking) |
| Abstract: | "In the moth Agrotis ipsilon, the behavioral response of males to the female-emitted sex pheromone increases throughout adult life and following a prior exposure to sex pheromone, whereas it is temporally inhibited after the onset of mating. This behavioral flexibility is paralleled with changes in neuronal sensitivity to pheromone signal within the primary olfactory centers, the antennal lobes. In the present study, we tested the hypothesis that neuroligins, post-synaptic transmembrane proteins known to act as mediators of neuronal remodeling, are involved in the olfactory modulation in A. ipsilon males. We cloned a full-length cDNA encoding neuroligin 1, which is expressed predominantly in brain and especially in antennal lobes. The level of neuroligin 1 expression in antennal lobes gradually raised from day-2 until day-4 of adult life, as well as at 24 h, 48 h and 72 h following pre-exposure to sex pheromone, and the temporal dynamic of these changes correlated with increased sex pheromone responsiveness. By contrast, there was no significant variation in antennal lobe neuroligin 1 expression during the post-mating refractory period. Taken together, these results highlight that age- and odor experience-related increase in sex pheromone responsiveness is linked to the overexpression of neuroligin 1 in antennal lobes, thus suggesting a potential role played by this post-synaptic cell-adhesion molecule in mediating the plasticity of the central olfactory system in A. ipsilon" |
| Keywords: | "Animals Cell Adhesion Molecules, Neuronal/genetics Female Male *Moths/genetics Neurons *Sex Attractants Neuroligin 1 Antennal lobes Mating behavior Moth Olfactory plasticity Sex pheromone;" |
| Notes: | "MedlineDurand, Nicolas Aguilar, Paleo Demondion, Elodie Bourgeois, Thomas Bozzolan, Francoise Debernard, Stephane eng England 2021/10/15 J Exp Biol. 2021 Nov 15; 224(22):jeb243184. doi: 10.1242/jeb.243184. Epub 2021 Nov 18" |
