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Respir Physiol Neurobiol

Title:		An electronic nose may sniff out amyotrophic lateral sclerosis
Author(s):		Dragonieri S; Quaranta VN; Carratu P; Ranieri T; Marra L; D'Alba G; Resta O;
Address:		"Pulmonology, University of Bari, Italy. Electronic address: silvano.dragonieri@uniba.it. Pulmonology, University of Bari, Italy"
Journal Title:		Respir Physiol Neurobiol
Year:		2016
Volume:		20160622
Issue:
Page Number:		22 - 25
DOI:		10.1016/j.resp.2016.06.005
ISSN/ISBN:		1878-1519 (Electronic) 1569-9048 (Linking)
Abstract:		"Amyothrophic lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a progressive degeneration of the cortical and spinal motor neuron. Exhaled molecular profiles that have potential in the diagnosis of several respiratory and systemic diseases can be obtained by analyzing human breath with an electronic nose. We hypothesized that exhaled molecular profiling may discriminate well-characterized patients with ALS from controls. 20 ALS patients (age: 63.5+/-12.3), and 20 healthy controls (age: 58.1+/-4.4) participated in a cross-sectional study. A Tedlar bag was used to collect exhaled breath by using a validated method. Bags were then sampled by an electronic nose (Cyranose 320). Statistical analysis on sensor responses was performed off-line by principal component analysis, linear discriminant analysis and ROC curves. Breathprints from patients with ALS were discriminated from healthy controls (CVA: 75.0%; p=0.003; AUC 0.795). Based on our results, patients with ALS can be discriminated from healthy controls. This suggests that exhaled breath analysis has potential for screening and/or diagnosis of this neuromuscular disease"
Keywords:		"Adult Aged Aged, 80 and over Amyotrophic Lateral Sclerosis/*complications Breath Tests Cross-Sectional Studies *Electronic Nose Female Humans Male Middle Aged Principal Component Analysis ROC Curve Respiration Disorders/*etiology Volatile Organic Compound;"
Notes:		"MedlineDragonieri, Silvano Quaranta, Vitaliano N Carratu, Pierluigi Ranieri, Teresa Marra, Lorenzo D'Alba, Giuseppina Resta, Onofrio eng Netherlands 2016/06/28 Respir Physiol Neurobiol. 2016 Oct; 232:22-5. doi: 10.1016/j.resp.2016.06.005. Epub 2016 Jun 22"