| Title: | An electronic nose distinguishes exhaled breath of patients with Malignant Pleural Mesothelioma from controls |
| Author(s): | Dragonieri S; van der Schee MP; Massaro T; Schiavulli N; Brinkman P; Pinca A; Carratu P; Spanevello A; Resta O; Musti M; Sterk PJ; |
| Address: | "Department of Respiratory Diseases, University of Bari, Bari, Italy. sdragonieri@hotmail.com" |
| DOI: | 10.1016/j.lungcan.2011.08.009 |
| ISSN/ISBN: | 1872-8332 (Electronic) 0169-5002 (Linking) |
| Abstract: | "BACKGROUND: Malignant Pleural Mesothelioma (MPM) is a tumour of the surface cells of the pleura that is highly aggressive and mainly caused by asbestos exposure. Electronic noses capture the spectrum of exhaled volatile organic compounds (VOCs) providing a composite biomarker profile (breathprint). OBJECTIVE: We tested the hypothesis that an electronic nose can discriminate exhaled air of patients with MPM from subjects with a similar long-term professional exposure to asbestos without MPM and from healthy controls. METHODS: 13 patients with a histology confirmed diagnosis of MPM (age 60.9+/-12.2 year), 13 subjects with certified, long-term professional asbestos exposure (age 67.2+/-9.8), and 13 healthy subjects without asbestos exposure (age 52.2+/-16.2) participated in a cross-sectional study. Exhaled breath was collected by a previously described method and sampled by an electronic nose (Cyranose 320). Breathprints were analyzed by canonical discriminant analysis on principal component reduction. Cross-validated accuracy (CVA) was calculated. RESULTS: Breathprints from patients with MPM were separated from subjects with asbestos exposure (CVA: 80.8%, sensitivity 92.3%, specificity 85.7%). MPM was also distinguished from healthy controls (CVA: 84.6%). Repeated measurements confirmed these results. CONCLUSIONS: Molecular pattern recognition of exhaled breath can correctly distinguish patients with MPM from subjects with similar occupational asbestos exposure without MPM and from healthy controls. This suggests that breathprints obtained by electronic nose have diagnostic potential for MPM" |
| Keywords: | Aged Asbestos/toxicity Breath Tests/*methods Case-Control Studies Cross-Sectional Studies Female Humans Male Mesothelioma/*diagnosis Middle Aged Occupational Exposure Pleural Neoplasms/*diagnosis Reproducibility of Results Sensitivity and Specificity; |
| Notes: | "MedlineDragonieri, Silvano van der Schee, Marc P Massaro, Tommaso Schiavulli, Nunzia Brinkman, Paul Pinca, Armando Carratu, Pierluigi Spanevello, Antonio Resta, Onofrio Musti, Marina Sterk, Peter J eng Controlled Clinical Trial Ireland 2011/09/20 Lung Cancer. 2012 Mar; 75(3):326-31. doi: 10.1016/j.lungcan.2011.08.009. Epub 2011 Sep 15" |
