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Nat Rev Chem

Title:		Induced volatolomics of pathologies
Author(s):		Djago F; Lange J; Poinot P;
Address:		"University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Materiaux de Poitiers (IC2MP), E.BiCoM Team, Poitiers, France. University of Poitiers, UMR CNRS 7285, Institut de Chimie des Milieux et Materiaux de Poitiers (IC2MP), E.BiCoM Team, Poitiers, France. pauline.poinot@univ-poitiers.fr"
Journal Title:		Nat Rev Chem
Year:		2021
Volume:		20210202
Issue:		3
Page Number:		183 - 196
DOI:		10.1038/s41570-020-00248-z
ISSN/ISBN:		2397-3358 (Electronic) 2397-3358 (Linking)
Abstract:		"Volatolomics allows us to elucidate cell metabolic processes in real time. In particular, a volatile organic compound (VOC) excreted from our bodies may be specific for a certain disease, such that measuring this VOC may afford a simple, fast, accessible and safe diagnostic approach. Yet, finding the optimal endogenous volatile marker specific to a pathology is non-trivial because of interlaboratory disparities in sample preparation and analysis, as well as high interindividual variability. These limit the sensitivity and specificity of volatolomics and its applications in biological and clinical fields but have motivated the development of induced volatolomics. This approach aims to overcome issues by measuring VOCs that result not from an endogenous metabolite but, rather, from the pathogen-specific or metabolic-specific enzymatic metabolism of an exogenous biological or chemical probe. In this Review, we introduce volatile-compound-based probes and discuss how they can be exploited to detect and discriminate pathogenic infections, to assess organ function and to diagnose and monitor cancers in real time. We focus on cases in which labelled probes have informed us about metabolic processes and consider the potential and drawbacks of the probes for clinical trials. Beyond diagnostics, VOC-based probes may also be effective tools to explore biological processes more generally"
Keywords:
Notes:		"PubMed-not-MEDLINEDjago, Fabiola Lange, Justin Poinot, Pauline eng Review England 2021/03/01 Nat Rev Chem. 2021 Mar; 5(3):183-196. doi: 10.1038/s41570-020-00248-z. Epub 2021 Feb 2"