| Title: | Diagnosis of primary lung cancer and benign pulmonary nodules: a comparison of the breath test and 18F-FDG PET-CT |
| Author(s): | Ding X; Lin G; Wang P; Chen H; Li N; Yang Z; Qiu M; |
| Address: | "Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China. Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, China. Department of Thoracic Surgery, Aerospace 731 Hospital, Beijing, China. Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China. Thoracic Oncology Institute, Peking University People's Hospital, Beijing, China. Breax Laboratory, PCAB Research Center of Breath and Metabolism, Beijing, China" |
| DOI: | 10.3389/fonc.2023.1204435 |
| ISSN/ISBN: | 2234-943X (Print) 2234-943X (Electronic) 2234-943X (Linking) |
| Abstract: | "With the application of low-dose computed tomography in lung cancer screening, pulmonary nodules have become increasingly detected. Accurate discrimination between primary lung cancer and benign nodules poses a significant clinical challenge. This study aimed to investigate the viability of exhaled breath as a diagnostic tool for pulmonary nodules and compare the breath test with 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)-computed tomography (CT). Exhaled breath was collected by Tedlar bags and analyzed by high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS). A retrospective cohort (n = 100) and a prospective cohort (n = 63) of patients with pulmonary nodules were established. In the validation cohort, the breath test achieved an area under the receiver operating characteristic curve (AUC) of 0.872 (95% CI 0.760-0.983) and a combination of 16 volatile organic compounds achieved an AUC of 0.744 (95% CI 0.7586-0.901). For PET-CT, the SUVmax alone had an AUC of 0.608 (95% CI 0.433-0.784) while after combining with CT image features, 18F-FDG PET-CT had an AUC of 0.821 (95% CI 0.662-0.979). Overall, the study demonstrated the efficacy of a breath test utilizing HPPI-TOFMS for discriminating lung cancer from benign pulmonary nodules. Furthermore, the accuracy achieved by the exhaled breath test was comparable with 18F-FDG PET-CT" |
| Keywords: | Pet-ct breath test early detection lung cancer pulmonary nodule; |
| Notes: | "PubMed-not-MEDLINEDing, Xiangxiang Lin, Guihu Wang, Peiyu Chen, Haibin Li, Nan Yang, Zhi Qiu, Mantang eng Switzerland 2023/06/19 Front Oncol. 2023 Jun 2; 13:1204435. doi: 10.3389/fonc.2023.1204435. eCollection 2023" |
