| Title: | Identification of profiles of volatile organic compounds in exhaled breath by means of an electronic nose as a proposal for a screening method for breast cancer: a case-control study |
| Author(s): | Diaz de Leon-Martinez L; Rodriguez-Aguilar M; Gorocica-Rosete P; Dominguez-Reyes CA; Martinez-Bustos V; Tenorio-Torres JA; Ornelas-Rebolledo O; Cruz-Ramos JA; Balderas-Segura B; Flores-Ramirez R; |
| Address: | "Center for Applied Research in Environment and Health, CIACYT, Medicine Faculty, Autonomous University of San Luis Potosi, Av. Venustiano Carranza 2405, CP 78210, San Luis Potosi, SLP, Mexico. Biochemestry research department of National Institute Respiratory Diseases, Ismael Cosio Villegas, Mexico city, Mexico. Fundacion del Cancer de Mama A.C., Mexico city, Mexico. Labinnova Center of Investigation in Breath for early detection diseases, Guadalajara, Mexico. Instituto Jalisciense de Cancerologia, Guadalajara, Mexico. CONACYT Research Fellow, Coordinacion para la Innovacion y Aplicacion de la Ciencia y la Tecnologia (CIACYT), Universidad Autonoma de San Luis Potosi, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Seccion, CP 78210, San Luis Potosi, SLP, Mexico" |
| ISSN/ISBN: | 1752-7163 (Electronic) 1752-7155 (Linking) |
| Abstract: | "The objective of the present study was to identify volatile prints from exhaled breath, termed breath-print, from breast cancer (BC) patients and healthy women by means of an electronic nose and to evaluate its potential use as a screening method. A cross-sectional study was performed on 443 exhaled breath samples from women, of whom 262 had been diagnosed with BC by biopsy and 181 were healthy women (control group). Breath-print analysis was performed utilizing the Cyranose 320 electronic nose. Group data were evaluated by principal component analysis (PCA), canonical discriminant analysis (CDA), and support vector machine (SVM), and the test's diagnostic power was evaluated by means of receiver operating characteristic (ROC) curves. The results obtained using the model generated from the CDA, which best describes the behavior of the assessed groups, indicated that the breath-print of BC patients was different from that of healthy women and that they presented with a variability of up to 98.8% and a correct classification of 98%. The sensitivity, specificity, negative predictive value, and positive predictive value reached 100% according to the ROC curve. The present study demonstrates the capability of the electronic nose to separate between healthy subjects and BC patients. This research could have a beneficial impact on clinical practice as we consider that this test could probably be used at the first point before the application of established gold tests (mammography, ultrasound, and biopsy) and substantially improve screening tests in the general population" |
| Keywords: | Adult Breast Neoplasms/*diagnosis Breath Tests/*methods Case-Control Studies Cross-Sectional Studies Discriminant Analysis *Electronic Nose *Exhalation Female Humans Middle Aged Principal Component Analysis ROC Curve Reproducibility of Results Volatile Or; |
| Notes: | "MedlineDiaz de Leon-Martinez, Lorena Rodriguez-Aguilar, Maribel Gorocica-Rosete, Patricia Dominguez-Reyes, Carlos Alberto Martinez-Bustos, Veronica Tenorio-Torres, Juan Alberto Ornelas-Rebolledo, Omar Cruz-Ramos, Jose Alfonso Balderas-Segura, Berenice Flores-Ramirez, Rogelio eng Observational Study Research Support, Non-U.S. Gov't England 2020/07/23 J Breath Res. 2020 Sep 22; 14(4):046009. doi: 10.1088/1752-7163/aba83f" |
