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Ecotoxicol Environ Saf

Title:		"Assessment of 2-allyl-4,5-dimethoxyphenol safety and attractiveness to mature males of Bactrocera dorsalis (Hendel)"
Author(s):		Deng SZ; Li XY; Wang ZM; Wang JB; Han DY; Fan JH; Zhao Q; Liu H; Wang XS;
Address:		"College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, Henan Province, China. Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, China. College of Horticulture and Plant Protection, Henan University of Science and Technology, Luoyang 471023, Henan Province, China. Electronic address: liuhuan@haust.edu.cn. Henan Key Laboratory of Cancer Epigenetics, Cancer Hospital, The First Affiliated Hospital, College of Clinical Medicine, Medical College of Henan University of Science and Technology, Luoyang, China. Electronic address: xshuaiw@haust.edu.cn"
Journal Title:		Ecotoxicol Environ Saf
Year:		2021
Volume:		20210804
Issue:
Page Number:		112567 -
DOI:		10.1016/j.ecoenv.2021.112567
ISSN/ISBN:		1090-2414 (Electronic) 0147-6513 (Linking)
Abstract:		"Males of the Oriental fruit fly Bactrocera dorsalis (Hendel) are highly attracted to, and compulsively feed, on methyl eugenol (ME). ME is converted into 2-allyl-4,5-dimethoxyphenol (DMP) and (E)-coniferyl alcohol (E-CF), which are temporarily sequestered in the fly's rectal gland prior to being released at dusk. Previous research initially confirmed that DMP is a relatively strong lure to B. dorsalis males. However, the characteristics of males' response to DMP and toxicology of DMP remains largely unclear. In our study, we demonstrated that DMP was more attractive to sexually mature males than E-CF tested in laboratory bioassays. Interestingly, the responsiveness of mature males to DMP was not uniform throughout the day, eliciting the highest response during the day and dropping to a low level at night. Furthermore, there were no significant differences between the olfactory responses of virgin and mated mature males to DMP. No obvious signs of toxic symptom and deaths were observed in mice during a 14-day acute oral toxicity testing. Further, toxicologically significant changes were not observed in body weight, water intake, food consumption, and absolute and relative organ weights between control and treated groups, implying DMP could be regarded as nontoxic. Lastly, the cytotoxicity data of DMP on cells showed that it exhibited no significant cytotoxicity to normal human and mouse cells. Taken together, results from both the acute and cellular toxicity experiments demonstrated the nontoxic nature of DMP. In conclusion, DMP shows promise as an effective and eco-friendly lure for B. dorsalis males, and may contribute to controlling B. dorsalis in the flied"
Keywords:		Animals Eugenol/analogs & derivatives Male Mice Reproduction *Sex Attractants *Tephritidae Acute toxicity Cytotoxicity Dmp Methyl eugenol Olfactometer bioassay Oriental fruit fly;
Notes:		"MedlineDeng, Shu-Zhen Li, Xin-Yang Wang, Zi-Ming Wang, Jun-Bo Han, Dan-Yang Fan, Jia-Hao Zhao, Qi Liu, Huan Wang, Xin-Shuai eng Netherlands 2021/08/08 Ecotoxicol Environ Saf. 2021 Oct 15; 223:112567. doi: 10.1016/j.ecoenv.2021.112567. Epub 2021 Aug 4"