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Environ Sci Pollut Res Int

Title:		Chemical diversity and biological activities of essential oils from native populations of Clinopodium menthifolium subsp. ascendens (Jord.) Govaerts
Author(s):		Debbabi H; El Mokni R; Nardoni S; Chaieb I; Maggi F; Nzekoue FK; Caprioli G; Hammami S;
Address:		"Research Unit 13ES63, Applied Chemistry and Environment, Faculty of Sciences of Monastir, University of Monastir, 5000, Monastir, Tunisia. Department Pharmaceutical Sciences 'A', Laboratory of Botany, Cryptogamy and Plant Biology, Faculty of Pharmacy of Monastir, University of Monastir, BP 207 Avenue Avicenna, 5000, Monastir, Tunisia. IRESA, Laboratory of Forest Ecology, I.N.R.G.R.E.F, BP N degrees 10, 2080, Ariana, Tunisia. Dipartimento di Scienze Veterinarie, Universita degli Studi di Pisa, 56124, Pisa, PI, Italy. Regional Centre of Research on Horticulture and Organic Agriculture, University of Sousse, 57, Chott Mariem, TN-4042, Sousse, Tunisia. Dipartimento di Scienze Chimiche, School of Pharmacy, University of Camerino, Camerino, Italy. Research Unit 13ES63, Applied Chemistry and Environment, Faculty of Sciences of Monastir, University of Monastir, 5000, Monastir, Tunisia. h_saoussen@yahoo.fr"
Journal Title:		Environ Sci Pollut Res Int
Year:		2021
Volume:		20201114
Issue:		11
Page Number:		13624 - 13633
DOI:		10.1007/s11356-020-11523-3
ISSN/ISBN:		1614-7499 (Electronic) 0944-1344 (Linking)
Abstract:		"This study is focused on the analysis of regional variation of the chemical compositions of three Clinopodium menthifolium subsp. ascendens (Jord.) Govaerts Tunisian accession, as well as their inhibition toward fungi and insect pests. The diversity of the chemical constituents and biological activities in front of the aforementioned variations was found to be remarkable. Essential oils were obtained by hydrodistillation of the aerial parts and analyzed by gas chromatography-mass spectrometry (GC-MS). A total of 41, 42, and 30 compounds were identified respectively from Clinopodium menthifolium essential oils harvested from three Tunisian regions, namely Ain-Draham (ADEO), Babouch (BEO), and Tabarka (TEO). All analyzed oils were rich in oxygenated monoterpenes with different major constituents. Piperitenone (34.5%), cis-piperitone oxide (26.1%), and pulegone (47.9%) were the dominant compounds in the three volatile oils, respectively. The antifungal activity was investigated in vitro using six targeted fungal strains (Aspergillus flavus, Aspergillus terreus, Candida albicans, Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes). The toxicity and repellency of essential oils were evaluated against the stored product pest Tribolium confusum. The tested samples were differently effective toward the target fungi and the pest depending on the variability of their chemical compositions. BEO exhibited the highest fungitoxic properties toward A. terreus mold, M. canis dermatophyte, and C. albicans yeast (the MIC values ranged from 40 to 400 mug mL(-1)). In addition, the data showed that TEO repelled T. confusum moderately (PR = 42.5% at 2 h after exposure). Concerning the contact treatment, both ADEO and BEO were proved to possess slightly toxic effects toward T. confusum pest (% of mortality 27.5-32.5% at 5% concentration). The results showed that the geographic origin greatly influenced the chemical composition and the associated bioactivities of Clinopodium menthifolium subsp. ascendens"
Keywords:		"Antifungal Agents Arthrodermataceae Aspergillus Microbial Sensitivity Tests Microsporum *Oils, Volatile Antifungal and insecticidal activities Chemical diversity Clinopodium menthifolium subsp.ascendens (Jord.) Govaerts Essential oils;"
Notes:		"MedlineDebbabi, Haifa El Mokni, Ridha Nardoni, Simona Chaieb, Ikbal Maggi, Filippo Nzekoue, Franks Kamgang Caprioli, Giovanni Hammami, Saoussen eng Germany 2020/11/16 Environ Sci Pollut Res Int. 2021 Mar; 28(11):13624-13633. doi: 10.1007/s11356-020-11523-3. Epub 2020 Nov 14"