| Title: | Breath-print analysis by e-nose for classifying and monitoring chronic liver disease: a proof-of-concept study |
| Author(s): | De Vincentis A; Pennazza G; Santonico M; Vespasiani-Gentilucci U; Galati G; Gallo P; Vernile C; Pedone C; Antonelli Inc; Picardi A; |
| Address: | "Clinical Medicine and Hepatology Department, Campus Bio-Medico University, via Alvaro del Portillo 200, 00128 Rome, Italy. Center for Integrated Research - CIR, Unit of Electronics for Sensor Systems, Campus Bio-Medico University, via Alvaro del Portillo 200, 00128 Rome, Italy. Chair of Geriatrics, Unit of Respiratory Pathophysiology, Campus Bio-Medico University, via Alvaro del Portillo 200, 00128 Rome, Italy. San Raffaele- Cittadella della Carita Foundation, Taranto, Italy" |
| ISSN/ISBN: | 2045-2322 (Electronic) 2045-2322 (Linking) |
| Abstract: | "Since the liver plays a key metabolic role, volatile organic compounds in the exhaled breath might change with type and severity of chronic liver disease (CLD). In this study we analysed breath-prints (BPs) of 65 patients with liver cirrhosis (LC), 39 with non-cirrhotic CLD (NC-CLD) and 56 healthy controls by the e-nose. Distinctive BPs characterized LC, NC-CLD and healthy controls, and, among LC patients, the different Child-Pugh classes (sensitivity 86.2% and specificity 98.2% for CLD vs healthy controls, and 87.5% and 69.2% for LC vs NC-CLD). Moreover, the area under the BP profile, derived from radar-plot representation of BPs, showed an area under the ROC curve of 0.84 (95% CI 0.76-0.91) for CLD, of 0.76 (95% CI 0.66-0.85) for LC, and of 0.70 (95% CI 0.55-0.81) for decompensated LC. By applying the cut-off values of 862 and 812, LC and decompensated LC could be predicted with high accuracy (PPV 96.6% and 88.5%, respectively). These results are proof-of-concept that the e-nose could be a valid non-invasive instrument for characterizing CLD and monitoring hepatic function over time. The observed classificatory properties might be further improved by refining stage-specific breath-prints and considering the impact of comorbidities in a larger series of patients" |
| Keywords: | Adult Aged Breath Tests/*instrumentation Electronic Nose Female Humans Liver Cirrhosis/*diagnosis Liver Diseases/*classification/pathology Male Middle Aged ROC Curve Sensitivity and Specificity; |
| Notes: | "MedlineDe Vincentis, Antonio Pennazza, Giorgio Santonico, Marco Vespasiani-Gentilucci, Umberto Galati, Giovanni Gallo, Paolo Vernile, Chiara Pedone, Claudio Antonelli Incalzi, Raffaele Picardi, Antonio eng England 2016/05/06 Sci Rep. 2016 May 5; 6:25337. doi: 10.1038/srep25337" |
