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Can J Microbiol

Title:		Adhesion and biofilm formation by the opportunistic pathogen Candida tropicalis: what do we know?
Author(s):		de Souza CM; Dos Santos MM; Furlaneto-Maia L; Furlaneto MC;
Address:		"Department of Microbiology, Parana State University of Londrina, Parana, Brazil. C.P. 6001, 86051990. Technological Federal University of Parana, Parana, Brazil"
Journal Title:		Can J Microbiol
Year:		2023
Volume:		20230221
Issue:		6
Page Number:		207 - 218
DOI:		10.1139/cjm-2022-0195
ISSN/ISBN:		1480-3275 (Electronic) 0008-4166 (Linking)
Abstract:		"Candida tropicalis is among the most important Candida species in terms of epidemiology, virulence and resistance. Considering the increase in C. tropicalis incidence and high rates of mortality associated with this species, knowledge of its adhesion and biofilm formation abilities is needed. These traits determine the persistence and survival of yeast on different indwelling medical devices and host sites. C. tropicalis is among the most adherent Candida species, and it has been described as a strong biofilm producer. Environmental factors, phenotypic switching and quorum sensing molecules can affect adhesion and biofilm growth. C. tropicalis can form sexual biofilms, which are promoted by mating pheromones. C. tropicalis biofilms are regulated by a wide and complex network of genes and signaling pathways that are currently poorly understood. Morphological studies showed improved biofilm architecture, which was related to the expression of several hypha-specific genes. Based on recent updates, research is still needed to increase our knowledge on the genetic network of adhesion and biofilm formation by C. tropicalis, as well as the protein diversity that mediates interactions with inert materials and biological surfaces. Here, we have reviewed the main aspects related to adhesion and biofilm formation in C. tropicalis and summarized current knowledge on the significance of these virulence factors in this opportunistic species"
Keywords:		*Candida tropicalis/genetics *Gene Regulatory Networks Biofilms Quorum Sensing Phenotype Candida tropicalis adherence adhesins biofilm regulation biofilm resistance;
Notes:		"Medlinede Souza, Cassia M Dos Santos, Murilo M Furlaneto-Maia, Luciana Furlaneto, Marcia C eng Review Canada 2023/02/23 Can J Microbiol. 2023 Jun 1; 69(6):207-218. doi: 10.1139/cjm-2022-0195. Epub 2023 Feb 21"