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Anal Bioanal Chem

Title:		A novel method for the determination of three volatile organic compounds in exhaled breath by solid-phase microextraction-ion mobility spectrometry
Author(s):		Allafchian AR; Majidian Z; Ielbeigi V; Tabrizchi M;
Address:		"Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan, 84156-83111, Iran. Allafchian@cc.iut.ac.ir. Nanotechnology and Advanced Materials Institute, Isfahan University of Technology, Isfahan, 84156-83111, Iran. Department of Chemistry, Isfahan University of Technology, Isfahan, 84156-83111, Iran"
Journal Title:		Anal Bioanal Chem
Year:		2016
Volume:		20151111
Issue:		3
Page Number:		839 - 847
DOI:		10.1007/s00216-015-9170-8
ISSN/ISBN:		1618-2650 (Electronic) 1618-2642 (Linking)
Abstract:		"A method was carried out for the quantitative determination of the concentrations of volatile organic compounds (VOCs) using solid-phase microextraction and ion mobility spectrometry (SPME-IMS). This method was optimized and evaluated. The best results were obtained at sorption temperature 70 degrees C, desorption temperature 200 degrees C, and extraction time 15 min. Under the optimized conditions, the linear dynamic range was found to be 0.01-4.0 ppb (R(2) > 0.995), 2.3-400 ppm (R(2) > 0.994), and 2.5-76 ppb (R(2) > 0.998) for acetone, acetaldehyde, and acetonitrile, respectively. The detection limits for acetone, acetaldehyde, and acetonitrile were 0.001 ppb, 0.18 ppm, and 0.22 ppb, respectively. As a practical application, the method was applied for the determination of acetone, acetaldehyde, and acetonitrile in human breath matrix. Therefore, the proposed method was found to be effective and simple enough to be strongly recommended for real sample analysis"
Keywords:		Adult Breath Tests/*methods Female Humans Mass Spectrometry/*methods Solid Phase Microextraction/*methods Volatile Organic Compounds/*chemistry/isolation & purification Gold nanoparticles Ion mobility spectrometry Sol gel Solid-phase microextraction;
Notes:		"MedlineAllafchian, Ali Reza Majidian, Zahra Ielbeigi, Vahideh Tabrizchi, Mahmoud eng Evaluation Study Research Support, Non-U.S. Gov't Germany 2015/11/13 Anal Bioanal Chem. 2016 Jan; 408(3):839-47. doi: 10.1007/s00216-015-9170-8. Epub 2015 Nov 11"