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Neurotoxicol Teratol

Title:		"A novel preclinical model of environment-like combined benzene, toluene, ethylbenzene, and xylenes (BTEX) exposure: Behavioral and neurochemical findings"
Author(s):		Davidson CJ; Svenson DW; Hannigan JH; Perrine SA; Bowen SE;
Address:		"Department of Psychology, Wayne State University, Detroit, MI, USA. Department of Psychology, Wayne State University, Detroit, MI, USA; Department of Obstetrics & Gynecology, Wayne State University, Detroit, MI, USA; Merrill Palmer Skillman Institute for Child & Family Development, Wayne State University, Detroit, MI, USA; Center for Urban Responses to Environmental Stressors, Wayne State University, Detroit, MI, USA. Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA; John D. Dingell VA Medical Center, Detroit, MI, USA. Department of Psychology, Wayne State University, Detroit, MI, USA; Center for Urban Responses to Environmental Stressors, Wayne State University, Detroit, MI, USA. Electronic address: scott.bowen@wayne.edu"
Journal Title:		Neurotoxicol Teratol
Year:		2022
Volume:		20220212
Issue:
Page Number:		107076 -
DOI:		10.1016/j.ntt.2022.107076
ISSN/ISBN:		1872-9738 (Electronic) 0892-0362 (Linking)
Abstract:		"Environmental exposure to toxicants is a major health issue and a leading risk factor for premature mortality worldwide, including environmental exposures to volatile organic compounds (VOCs), specifically Benzene, Toluene, Ethylbenzene, and Xylene (BTEX). While exposure to these compounds individually has shown behavioral and neurochemical effects, this investigation examined the impact of exposure to combined BTEX using a preclinical model. Male Swiss Webster mice were exposed to BTEX vapors designed to approximate environmental levels in urban communities. Animals were exposed to one of four treatment conditions: a 0-ppm (air control), two BTEX groups representing levels of environmental-like exposure, and a fourth group modeling occupational-like exposure. These exposures were conducted in 1.5-h sessions, 2 sessions/day, 5 days/week, for 3 weeks. Effects on coordination (i.e., rotarod and inverted screen test), learning and memory (i.e., Y-maze), and locomotor behavior (i.e., movement during exposure) were assessed during and after exposure. Monoamine levels in the medial prefrontal cortex and nucleus accumbens were assessed immediately following exposure. Effects of BTEX exposure were found on the variance of locomotor activity but not in other behavioral or neurochemical assessments. These results indicate that the combination of inhaled BTEX at environmentally representative concentrations has demonstrable, albeit subtle, effects on behavior"
Keywords:		*Air Pollutants Animals Benzene/analysis/toxicity Benzene Derivatives/analysis/toxicity Male Mice Toluene/toxicity *Xylenes/analysis/toxicity Animal models Btex Environmental toxicology Volatile organic solvents;neuroscience;
Notes:		"MedlineDavidson, Cameron J Svenson, D W Hannigan, John H Perrine, Shane A Bowen, Scott E eng P30 ES020957/ES/NIEHS NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2022/02/16 Neurotoxicol Teratol. 2022 May-Jun; 91:107076. doi: 10.1016/j.ntt.2022.107076. Epub 2022 Feb 12"