| Title: | The Detection of Wound Infection by Ion Mobility Chemical Analysis |
| Author(s): | Daulton E; Wicaksono A; Bechar J; Covington JA; Hardwicke J; |
| Address: | "School of Engineering, University of Warwick, Coventry CV4 7AL, UK. Warwick Medical School, University of Warwick, Medical School Building, Coventry CV4 7HL, UK. Department of Plastic Surgery, University Hospitals of Coventry and Warwickshire NHS Trust, Clifford Bridge Road, Coventry, CV2 2DX, UK" |
| ISSN/ISBN: | 2079-6374 (Electronic) 2079-6374 (Linking) |
| Abstract: | "Surgical site infection represents a large burden of care in the National Health Service. Current methods for diagnosis include a subjective clinical assessment and wound swab culture that may take several days to return a result. Both techniques are potentially unreliable and result in delays in using targeted antibiotics. Volatile organic compounds (VOCs) are produced by micro-organisms such as those present in an infected wound. This study describes the use of a device to differentiate VOCs produced by an infected wound vs. colonised wound. Malodourous wound dressings were collected from patients, these were a mix of post-operative wounds and vascular leg ulcers. Wound microbiology swabs were taken and antibiotics commenced as clinically appropriate. A control group of soiled, but not malodorous wound dressings were collected from patients who had a split skin graft (SSG) donor site. The analyser used was a G.A.S. GC-IMS. The results from the samples had a sensitivity of 100% and a specificity of 88%, with a positive predictive value of 90%. An area under the curve (AUC) of 91% demonstrates an excellent ability to discriminate those with an infected wound from those without. VOC detection using GC-IMS has the potential to serve as a diagnostic tool for the differentiation of infected and non-infected wounds and facilitate the treatment of wound infections that is cost effective, non-invasive, acceptable to patients, portable, and reliable" |
| Keywords: | Blood Chemical Analysis/*methods Humans Ions/*metabolism Wound Infection/*diagnosis Gc-ims.Voc diagnosis gas analysis wound infection; |
| Notes: | "MedlineDaulton, Emma Wicaksono, Alfian Bechar, Janak Covington, James A Hardwicke, Joseph eng RCS Pump Priming Award 2016/17/Royal college of Surgeons/ Switzerland 2020/03/04 Biosensors (Basel). 2020 Feb 29; 10(3):19. doi: 10.3390/bios10030019" |
