| Title: | A novel female influences delta 9-THC effects on plasma hormone levels in male mice |
| Author(s): | Dalterio S; Bartke A; Mayfield D; |
| DOI: | 10.1016/0091-3057(81)90188-x |
| ISSN/ISBN: | 0091-3057 (Print) 0091-3057 (Linking) |
| Abstract: | "Exposure to delta 9-tetrahydrocannabinol (THC) (50 mg/kg) alters the endocrine responsivity of male mice to female-related exteroceptive stimuli. Exposure to a novel female prevents or delays the THC-induced decrease in plasma testosterone (T) and luteinizing hormone (LH) levels. These hormonal alterations are apparently not due to the LH-releasing effects of female-related pheromonal or tactile cues, since administration of luteinizing hormone releasing factor (LRF) did not mimic the effects of a novel female on plasma T levels in THC-treated males. Exposure to a much lower dose of THC (0.5 mg/kg) did augment the LRF-induced increases in plasma T levels suggesting a possible synergism between gonadotropins and THC on androgen production. The present findings suggest that THC-induced alterations in hormonal status may be influenced by complex social or environmental factors" |
| Keywords: | Animals Dronabinol/*pharmacology Gonadotropin-Releasing Hormone/pharmacology Hormones/*blood Male Mice Testosterone/blood Time Factors; |
| Notes: | "MedlineDalterio, S Bartke, A Mayfield, D eng 1 R01 DA 02342-01/DA/NIDA NIH HHS/ 5P30-HD 10202/HD/NICHD NIH HHS/ Research Support, U.S. Gov't, P.H.S. 1981/08/01 Pharmacol Biochem Behav. 1981 Aug; 15(2):281-4. doi: 10.1016/0091-3057(81)90188-x" |
