| Title: | Amazonian medicinal smokes: Chemical analysis of Burseraceae pitch (breu) oleoresin smokes and insights into their use on headache |
| Author(s): | da Cruz Albino R; Braz MM; Bizzo HR; Santana da Silva RV; Leitao SG; Ribeiro de Oliveira D; |
| Address: | "Laboratory of Bioprospection and Applied Ethnopharmacology, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil. Electronic address: rayanealbino@gmail.com. Laboratory of Bioprospection and Applied Ethnopharmacology, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil. Electronic address: marcellemaga@gmail.com. Embrapa Agroindustria de Alimentos, 23020-470, Rio de Janeiro, Brazil. Electronic address: humberto.bizzo@embrapa.br. Laboratory of Molecular and Environmental Organic Geochemistry, Federal University of Rio de Janeiro, 21941-598, Rio de Janeiro, Brazil. Electronic address: raquelvieira@iq.ufrj.br. Laboratorio de Fitoquimica e Farmacognosia, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil. Electronic address: sgleitao@pharma.ufrj.br. Laboratory of Bioprospection and Applied Ethnopharmacology, Federal University of Rio de Janeiro, 21941-902, Rio de Janeiro, Brazil. Electronic address: danilopharma@gmail.com" |
| DOI: | 10.1016/j.jep.2021.114165 |
| ISSN/ISBN: | 1872-7573 (Electronic) 0378-8741 (Linking) |
| Abstract: | "ETHNOPHARMACOLOGICAL RELEVANCE: In Latin American Traditional Medicine, the use of Burseraceae oleoresins for headache relief is widespread. In the quilombola (maroon) communities of the municipality of Oriximina, Para State, Brazil, Burseraceae oleoresins are burned as incenses to treat headache; an effect attained by inhaling the smokes. AIM OF THE STUDY: This study was designed to investigate the scientific rationale behind the use of Burseraceae pitch oleoresin smokes on headache by identifying its chemical constituents and discussing whether they could be beneficial for headache treatment. MATERIALS AND METHODS: Two samples of pitch oleoresins were purchased from Amazonian public markets; one of them marketed as 'breu preto' (black pitch), and the other as 'breu branco' (white pitch). The smoke headspaces produced upon burning these oleoresins were collected and analysed by GC-MS. For comparative purposes, the triterpenoid fingerprints of the oleoresins' dichloromethane extracts and profiles of the essential oils were also obtained by GC-MS - and GC-FID, in the case of the essential oils. RESULTS: A total of 32 compounds were detected in black and white pitch oleoresin smokes. All smoke headspaces of the pitch oleoresins shared the presence of volatile terpenoids (e.g., alpha-terpineol) and triterpenoids (e.g., alpha-amyrin, beta-amyrin, alpha-amyrone, and beta-amyrone). These compounds were also present in the crude resins and could potentially be responsible for anti-inflammatory, antinociceptive and analgesic effects on headache. CONCLUSIONS: The pharmacological data on the terpenoids detected in the Burseraceae pitch smokes strongly support their traditional use for headache, but their actual effects upon inhalation have yet to be determined" |
| Keywords: | "Burseraceae/*chemistry Gas Chromatography-Mass Spectrometry Headache/*therapy Humans Latin America Medicine, Traditional Oils, Volatile/chemistry Plant Extracts/*chemistry/therapeutic use Smoke/*analysis Essential oils Mass spectrometry Plant-derived smok;" |
| Notes: | "Medlineda Cruz Albino, Rayane Braz, Marcelle Magalhaes Bizzo, Humberto Ribeiro Santana da Silva, Raquel Vieira Leitao, Suzana Guimaraes Ribeiro de Oliveira, Danilo eng Ireland 2021/05/02 J Ethnopharmacol. 2021 Aug 10; 276:114165. doi: 10.1016/j.jep.2021.114165. Epub 2021 Apr 28" |
