| Title: | A Method to Quantitatively Assess Dermal Exposure to Volatile Organic Compounds |
| Author(s): | Creta M; Poels K; Thoelen L; Vranckx K; Collaerts P; Jansen F; Vangeel M; Godderis L; Duca RC; Vanoirbeek JAJ; |
| Address: | "Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 35 - 6th floor box 7001, 3000 , Leuven, Belgium, Belgium. Janssen Pharmaceutical NV, EHS Janssen Campus Belgium, Janssen Pharmaceuticalaan3, B-2440 Geel, Belgium. Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven, Kapucijnenvoer 35 - 6th floor box 7001, 3000, Leuven, Belgium, Belgium. Idewe, External Service for Prevention and Protection at Work, Interleuvenlaan 58, 3001 Heverlee, Belgium" |
| ISSN/ISBN: | 2398-7316 (Electronic) 2398-7308 (Linking) |
| Abstract: | "Assessing dermal exposure of workers to noxious chemicals becomes increasingly important in industrial settings. Among various chemicals, volatile organic compounds (VOCs) are widely used in industrialized countries, but still there are no validated methodologies able to accurately quantify skin exposure. In this study, we developed a sensitive methodology based on activated charcoal cloth (ACC) to quantitatively assess skin exposure to 181 VOCs. The majority of the VOCs (156) showed a constant desorption efficiency (DE) of ~100% over the studied concentration range. Seven VOCs showed a concentration dependency for the DEs, which we described by a Dubinin-Raduskevich desorption isotherm. For 18 compounds, the DEs were situated below 80% but showed to be constant over the concentration range. All tested VOCs showed a good storage stability on ACC, especially at -80 degrees C storage. Only for n-pentane there was a decrease of ~40% when it was stored for a month. In a controlled environment test, ACC has shown to reflect well the increasing concentrations of VOCs in the air with a high linearity (R2 >/= 0.812, except for gamma-butyrolactone where R2 = 0.570). In this study, we show that ACC is a suitable sampling material for quantitatively assessing dermal exposure to 181 VOCs in terms of sensitivity and DE. This method will allow more studies that are detailed on dermal exposure, which will lead to a better assessment of skin exposure in occupational settings" |
| Keywords: | "Air Pollutants, Occupational/*analysis *Charcoal Environmental Monitoring/instrumentation/*methods Humans Occupational Exposure/*analysis Skin Volatile Organic Compounds/*analysis activated charcoal cloth charcoal pads dermal exposure assessment occupatio;" |
| Notes: | "MedlineCreta, Matteo Poels, Katrien Thoelen, Laurens Vranckx, Karine Collaerts, Peter Jansen, Fleur Vangeel, Michel Godderis, Lode Duca, Radu-Corneliu Vanoirbeek, Jeroen A J eng England 2017/10/14 Ann Work Expo Health. 2017 Oct 1; 61(8):975-985. doi: 10.1093/annweh/wxx054" |
