| Title: | In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring |
| Author(s): | Costa NO; Borges LI; Cavalcanti LF; Montagnini BG; Anselmo Franci JA; Kiss ACI; Gerardin DCC; |
| Address: | "Department of Physiological Sciences, State University of Londrina, Londrina, Parana, Brazil. Department of Morphology, Estomatology and Physiology, University of Sao Paulo, Sao Paulo, Brazil. Department of Physiology, Botucatu Biosciences Institute, Sao Paulo State University, Sao Paulo, Brazil" |
| ISSN/ISBN: | 1099-1263 (Electronic) 0260-437X (Linking) |
| Abstract: | "Triclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups (n = 8-11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post-natal day 21 and included in the study. No litter-mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre-implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring" |
| Keywords: | Animals Anti-Infective Agents/*toxicity Biomarkers/blood Blastocyst/drug effects/pathology Carbanilides/*toxicity Embryo Implantation/drug effects Embryo Loss Endocrine Disruptors/*toxicity Estradiol/blood Female Gestational Age Lactation Pregnancy *Prena; |
| Notes: | "MedlineCosta, Nathalia Orlandini Borges, Lorena Ireno Cavalcanti, Liara Freitas Montagnini, Bruno Garcia Anselmo Franci, Janete Aparecida Kiss, Ana Carolina Inhasz Gerardin, Daniela Cristina Ceccatto eng Research Support, Non-U.S. Gov't England 2019/12/24 J Appl Toxicol. 2020 Apr; 40(4):504-514. doi: 10.1002/jat.3922. Epub 2019 Dec 23" |
