« Previous Abstract"Mitochondrial phylogeny of pine cone beetles (Scolytinae, Conophthorus) and their affiliation with geographic area and host"    Next AbstractNonlinear response of ozone to emissions: source apportionment and sensitivity analysis »

Cell Metab

Title:		Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis
Author(s):		Cognigni P; Bailey AP; Miguel-Aliaga I;
Address:		"Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK"
Journal Title:		Cell Metab
Year:		2011
Volume:		13
Issue:		1
Page Number:		92 - 104
DOI:		10.1016/j.cmet.2010.12.010
ISSN/ISBN:		1932-7420 (Electronic) 1550-4131 (Print) 1550-4131 (Linking)
Abstract:		"The gastrointestinal tract is emerging as a key regulator of appetite and metabolism, but daunting neuroanatomical complexity has hampered identification of the relevant signals. Invertebrate models could provide a simple and genetically amenable alternative, but their autonomic nervous system and its visceral functions remain largely unexplored. Here we develop a quantitative method based on defecation behavior to uncover a central role for the Drosophila intestine in the regulation of nutrient intake, fluid, and ion balance. We then identify a key homeostatic role for autonomic neurons and hormones, including a brain-gut circuit of insulin-producing neurons modulating appetite, a vasopressin-like system essential for fluid homeostasis, and enteric neurons mediating sex peptide-induced changes in intestinal physiology. These conserved mechanisms of visceral control, analogous to those found in the enteric nervous system and hypothalamic/pituitary axis, enable the study of autonomic control in a model organism that has proved instrumental in understanding sensory and motor systems"
Keywords:		Acid-Base Equilibrium Animals Appetite Regulation/physiology Diet Diuresis Drosophila/metabolism/physiology Enteric Nervous System/*physiology Female Gastrointestinal Tract/*innervation/metabolism/physiology Gastrointestinal Transit Hemostatics Male Neuro;
Notes:		"MedlineCognigni, Paola Bailey, Andrew P Miguel-Aliaga, Irene eng WT083559/Wellcome Trust/United Kingdom Biotechnology and Biological Sciences Research Council/United Kingdom Research Support, Non-U.S. Gov't 2011/01/05 Cell Metab. 2011 Jan 5; 13(1):92-104. doi: 10.1016/j.cmet.2010.12.010"