« Previous AbstractSeasonal and reproductive variation in chemical constituents of scent signals in wild giant pandas    Next AbstractSymbiotic bacteria mediate volatile chemical signal synthesis in a large solitary mammal species »

Medicine (Baltimore)

Title:		Volatile organic compounds analysis as a potential novel screening tool for colorectal cancer: A systematic review and meta-analysis
Author(s):		Zhou W; Tao J; Li J; Tao S;
Address:		"Department of Emergency and Critical Care Medicine, Second Affiliated Hospital of Nanchang University. Department of Clinical Medicine, The Second Clinical Medical College, Nanchang University, Nanchang, China"
Journal Title:		Medicine (Baltimore)
Year:		2020
Volume:		99
Issue:		27
Page Number:		e20937 -
DOI:		10.1097/MD.0000000000020937
ISSN/ISBN:		1536-5964 (Electronic) 0025-7974 (Print) 0025-7974 (Linking)
Abstract:		"The purpose of this meta-analysis was to assess the usefulness of volatile organic compounds (VOC) as a potential novel biomarker for colorectal cancer (CRC).We systematically searched PubMed, Embase, Web of Science, and Cochrane Library databases for observational studies (published before November 25th, 2019; no language restrictions) comparing the VOC analysis between patients with CRC and healthy controls. We evaluated the pooled sensitivity, specificity, diagnostic odds ratio, positive and negative likelihood ratio, as well as summary receiver operating characteristic curve and area under the curve.We identified a total of 10 observational studies that included 381 patients with CRC and 436 healthy controls. Bivariate analysis yielded a pooled sensitivity of 0.82 (95% confidence interval [CI] = 0.77-0.86), specificity of 0.79 (95% CI = 0.71-0.85), positive likelihood ratio of 3.8 (95% CI = 2.8-5.3), and negative likelihood ratio of 0.23 (95% CI = 0.17-0.30). The area under the curve was 0.87 (95% CI = 0.84-0.90). The pooled diagnostic odds ratio was 17 (95% CI = 10-28). Sensitivity analysis indicated that the pooled results were stabilized. The Deeks' funnel plot asymmetry test (P = .41) suggested no potential publication bias.Our pooled data confirmed the associations between VOC analysis and CRC, highlighting the usefulness of VOC analysis as a potential novel screening tool for CRC. However, standardization of VOC collection and analysis methods for CRC screening is required in future research"
Keywords:		"Biomarkers, Tumor/analysis Colorectal Neoplasms/*diagnosis/physiopathology Early Detection of Cancer Humans Predictive Value of Tests Volatile Organic Compounds/*analysis;"
Notes:		"MedlineZhou, Wenchuan Tao, Jinxin Li, Jin Tao, Shaoyu eng Meta-Analysis Systematic Review 2020/07/08 Medicine (Baltimore). 2020 Jul 2; 99(27):e20937. doi: 10.1097/MD.0000000000020937"