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Mol Cell


Title:Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases
Author(s):Zhou P; Howley PM;
Address:"Department of Pathology, Harvard Medical School, Boston, MA 02115, USA"
Journal Title:Mol Cell
Year:1998
Volume:2
Issue:5
Page Number:571 - 580
DOI: 10.1016/s1097-2765(00)80156-2
ISSN/ISBN:1097-2765 (Print) 1097-2765 (Linking)
Abstract:"The S. cerevisiae SCFCdc4p ubiquitin-protein ligase complex promotes cell cycle transitions through degradation of cell cycle regulators. To investigate SCFCdc4p regulation in vivo, we examined the stability of individual SCFCdc4p components. Whereas Cdc53p and Skp1p were stable, Cdc4p, the F box-containing component responsible for substrate recognition, was short lived and subject to SCF-mediated ubiquitination. Grr1p, another F box component of SCF complexes, was also ubiquitinated. A stable truncated Cdc4pF-beta-gal hybrid protein capable of binding Skp1p and entering into an SCF complex interfered with proteolysis of SCF targets and inhibited cell proliferation. The finding that the F box-containing SCF components are unstable suggests a mechanism of regulating SCF function through ubiquitination and proteolysis of F box components"
Keywords:"Anaphase-Promoting Complex-Cyclosome CDC28 Protein Kinase, S cerevisiae/genetics/physiology *Carrier Proteins Cell Cycle/drug effects/genetics Cell Cycle Proteins/genetics/*metabolism *Cullin Proteins Cyclins/metabolism Cysteine Endopeptidases/genetics/me;"
Notes:"MedlineZhou, P Howley, P M eng Research Support, U.S. Gov't, P.H.S. 1998/12/09 Mol Cell. 1998 Nov; 2(5):571-80. doi: 10.1016/s1097-2765(00)80156-2"

 
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