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Gen Comp Endocrinol

Title:		A steroidal pheromone and spawning stimuli act via different neuroendocrine mechanisms to increase gonadotropin and milt volume in male goldfish Carassius auratus
Author(s):		Zheng W; Stacey NE;
Address:		"Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada"
Journal Title:		Gen Comp Endocrinol
Year:		1997
Volume:		105
Issue:		2
Page Number:		228 - 238
DOI:		10.1006/gcen.1996.6825
ISSN/ISBN:		0016-6480 (Print) 0016-6480 (Linking)
Abstract:		"In goldfish (Carassius auratus), pheromonal 17alpha, 20beta-dihydroxy-4-pregnen-3-one (17,20beta-P) and spawning stimuli (interaction with a sexually active female releasing prostaglandin pheromone) both increase gonadotropin-II (GtH-II) and milt volume. In the goldfish pituitary, GtH-II release is stimulated by gonadotropin-releasing hormone (GnRH) and inhibited by dopamine (DA). In this study, we investigated the possibility that 17,20beta-P and spawning stimuli act via separate neuroendocrine mechanisms by determining whether their effects on GtH-II could be selectively disrupted by injection of DA type-2 receptor (D-2) agonists (bromocryptine and LY171555) or a goldfish GnRH antagonist, [Ac-Delta3-Pro1, 4FD-Phe2, d-Trp3,6]-mGnRH (analog E). D-2 agonists blocked 17,20beta-P-induced increases in GtH-II and milt volume but did not affect spawning-induced responses. GnRH antagonist blocked 17,20beta-P-induced increases in GtH-II and milt volume, and spawning-induced GtH-II increase, but did not affect spawning-induced increase in milt volume. These results suggest that (1) pheromonal 17,20beta-P and spawning stimuli increase GtH-II increase via distinct neuroendocrine mechanisms, (2) the effect of pheromonal 17,20beta-P on increasing milt volume is GtH-II-dependent, and (3) the effect of spawning stimuli on increasing milt volume is GtH-II-independent"
Keywords:		"Animals Bromocriptine/administration & dosage/*pharmacology Dopamine Agonists/administration & dosage/*pharmacology Female Goldfish Gonadotropin-Releasing Hormone/administration & dosage/*analogs & derivatives/pharmacology Gonadotropins, Pituitary/*blood/;"
Notes:		"MedlineZheng, W Stacey, N E eng Research Support, Non-U.S. Gov't 1997/02/01 Gen Comp Endocrinol. 1997 Feb; 105(2):228-38. doi: 10.1006/gcen.1996.6825"