« Previous AbstractOptimization of the solid-phase microextraction method in the determination of Ixodes ricinus (L.) volatiles    Next AbstractReview: Derivatization in mass spectrometry--4. Formation of cyclic derivatives »

Eur J Mass Spectrom (Chichester)

Title:		Review: Derivatization in mass spectrometry--2. Acylation
Author(s):		Zaikin VG; Halket JM;
Address:		"Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia. zaikin@ips.ac.ru"
Journal Title:		Eur J Mass Spectrom (Chichester)
Year:		2003
Volume:		9
Issue:		5
Page Number:		421 - 434
DOI:		10.1255/ejms.576
ISSN/ISBN:		1469-0667 (Print) 1469-0667 (Linking)
Abstract:		"The present review is devoted to acylation as a widely employed derivatization procedure for protection of OH (alcohols, polyols, phenols, enols), SH (thiols) and NH (amines, amides) groups in order to increase volatility, improve chromatographic properties and, if possible, improve mass spectral properties of derivatives. Chemical aspects of derivatization and various acylating agents are characterized. Mass spectral [electron ionization (EI), chemical ionization (CI) and negative-ion (NI) CI] properties of derivatives that are helpful in identification, structure elucidation and quantitative determination of the analyzed compounds are discussed. Some recent analytical applications of the procedure in synthetic organic chemistry, clinical chemistry, environmental chemistry etc. are summarized"
Keywords:		Acylation Humans Mass Spectrometry/*methods Organic Chemicals/*analysis/chemistry;
Notes:		"MedlineZaikin, Vladimir G Halket, John M eng Review England 2003/11/19 Eur J Mass Spectrom (Chichester). 2003; 9(5):421-34. doi: 10.1255/ejms.576"