| Title: | Tea catechin EGCg suppresses the mgl gene associated with halitosis |
| Address: | "Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, MC850, 801 S. Paulina Street, Room 469J, Chicago, IL 60612-7212, USA" |
| ISSN/ISBN: | 1544-0591 (Electronic) 0022-0345 (Linking) |
| Abstract: | "Epigallocatechin gallate (EGCg), the main antimicrobial tea catechin, has been reported to inhibit growth and virulence factors of oral pathogens in vitro. Although the mechanism is unclear, the potential of EGCg in reducing halitosis caused by volatile sulfur compounds (VSCs) has been suggested. This study tested the hypothesis that EGCg reduces VSCs by suppressing mgl, the gene encoding L-methionine-alpha-deamino-gamma-mercaptomethane-lyase, responsible for methyl mercaptan (CH(3)SH) production by oral anaerobes. In this study, the effect of EGCg on in vitro growth, CH(3)SH production, and mgl gene expression in P. gingivalis W83 was investigated. EGCg inhibited growth of P. gingivalis W83 (MIC = 97.5 microg/mL) and was bactericidal (MBC = 187.5 microg/mL). At sub-MIC levels, EGCg inhibited CH(3)SH production, and mgl mRNA and protein expression (p < 0.05). We conclude that EGCg may represent a natural and alternative agent to the antimicrobial chemicals currently available for halitosis control" |
| Keywords: | "Anti-Infective Agents/*pharmacology Bacterial Proteins/drug effects Blotting, Western Carbon-Sulfur Lyases/*antagonists & inhibitors Catechin/*analogs & derivatives/pharmacology Enzyme Inhibitors/*pharmacology Halitosis/enzymology/*microbiology Humans Mic;" |
| Notes: | "MedlineXu, X Zhou, X D Wu, C D eng Comparative Study Research Support, Non-U.S. Gov't 2010/09/23 J Dent Res. 2010 Nov; 89(11):1304-8. doi: 10.1177/0022034510378682. Epub 2010 Sep 21" |
