« Previous AbstractSERS Approach to Probe the Adsorption Process of Trace Volatile Benzaldehyde on Layered Double Hydroxide Material    Next AbstractSte50p sustains mating pheromone-induced signal transduction in the yeast Saccharomyces cerevisiae »

J Comp Neurol

Title:		Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones
Author(s):		Xu F; Schaefer M; Kida I; Schafer J; Liu N; Rothman DL; Hyder F; Restrepo D; Shepherd GM;
Address:		"Department of Diagnostic Radiology, Yale Medical School, New Haven, Connecticut 06520, USA"
Journal Title:		J Comp Neurol
Year:		2005
Volume:		489
Issue:		4
Page Number:		491 - 500
DOI:		10.1002/cne.20652
ISSN/ISBN:		0021-9967 (Print) 0021-9967 (Linking)
Abstract:		"It is generally believed that the main olfactory system processes common odors and the accessory olfactory system is specifically for pheromones. The potential for these two systems to respond simultaneously to the same stimuli has not been fully explored due to methodological limitations. Here we examine this phenomenon using high-resolution functional magnetic resonance imaging (fMRI) to reveal simultaneously the responses in the main (MOB) and accessory olfactory bulbs (AOB) to odors and pheromones. Common odorants elicited strong signals in the MOB and weak signals in the AOB. 2-Heptanone, a known mouse pheromone, elicited strong signals in both the MOB and AOB. Urine odor, a complicated mixture of pheromones and odorants, elicited significant signals in limited regions of the MOB and large regions of the AOB. The fMRI results demonstrate that both the main and the accessory olfactory systems may respond to volatile compounds but with different selectivity, suggesting a greater integration of the two olfactory pathways than traditionally believed"
Keywords:		"Animals Evoked Potentials/physiology Female Ketones/pharmacology Magnetic Resonance Imaging Mice Mice, Inbred C57BL *Odorants Olfactory Bulb/anatomy & histology/drug effects/*physiology Olfactory Pathways/drug effects/physiology Pheromones/*pharmacology P;"
Notes:		"MedlineXu, Fuqiang Schaefer, Michele Kida, Ikuhiro Schafer, James Liu, Nian Rothman, Douglas L Hyder, Fahmeed Restrepo, Diego Shepherd, Gordon M eng DC-00086/DC/NIDCD NIH HHS/ DC-00566/DC/NIDCD NIH HHS/ DC-03710/DC/NIDCD NIH HHS/ DC-04732/DC/NIDCD NIH HHS/ MH-67528/MH/NIMH NIH HHS/ NS-37203/NS/NINDS NIH HHS/ Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 2005/07/19 J Comp Neurol. 2005 Sep 5; 489(4):491-500. doi: 10.1002/cne.20652"