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J Steroid Biochem Mol Biol

Title:		"Seasonal expressions of ERalpha, ERbeta, EGF, EGFR, PI3K and Akt in the scent glands of the muskrats (Ondatra zibethicus)"
Author(s):		Xie W; Zhao X; Guo L; Han Y; Yuan Z; Zhang H; Weng Q;
Address:		"Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China. Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China. Electronic address: haolinzhang@bjfu.edu.cn. Laboratory of Animal Physiology, College of Biological Sciences and Technology, Beijing Forestry University, Beijing, China. Electronic address: qiangweng@bjfu.edu.cn"
Journal Title:		J Steroid Biochem Mol Biol
Year:		2021
Volume:		20210812
Issue:
Page Number:		105961 -
DOI:		10.1016/j.jsbmb.2021.105961
ISSN/ISBN:		1879-1220 (Electronic) 0960-0760 (Linking)
Abstract:		"Epidermal growth factor (EGF) is an important autocrine and/or paracrine mediator of steroid hormones to stimulate growth and differentiation in mammals. The aim of this study is to investigate seasonal expressions of estrogen receptor alpha (ERalpha), estrogen receptor beta (ERbeta), EGF, epidermal growth factor receptor (EGFR), phosphatidylinositol 3-kinase (PI3K) and protein kinase B (Akt) in the scent glands of the muskrats during the breeding and non-breeding seasons. Histologically, three types of cells including the glandular cells, interstitial cells and epithelial cells were identified in the scent glands in both seasons. Immunohistochemical results showed that ERalpha, ERbeta, EGF, EGFR, PI3K and Akt were presented in the different types of cells of the scent glands during the breeding and non-breeding seasons. Transcriptome data of the scent glandular tissues from muskrats in the breeding and non-breeding seasons showed that differential seasonal changes might be related to the estrogen-EGFR signaling pathway. The gene expression levels of ERalpha, ERbeta, EGF, EGFR, PI3K were increased, while the gene expression level of Akt were decreased in the breeding season than those in the non-breeding season. Besides, the concentrations of 17beta-estradiol (E(2)) in the serum and the scent glandular tissues were remarkably higher in the breeding season than those of the non-breeding season. Taken together, our results suggested that EGFR signaling pathway may coordinate with ERs signaling to regulate the seasonal changes of the scent glandular functions"
Keywords:		Animals Arvicolinae/*genetics/metabolism China Epidermal Growth Factor/*genetics/metabolism ErbB Receptors/*genetics/metabolism Estrogen Receptor alpha/*genetics/metabolism Estrogen Receptor beta/*genetics/metabolism Gene Expression Regulation Male Phosph;
Notes:		"MedlineXie, Wenqian Zhao, Xinyu Guo, Li Han, Yingying Yuan, Zhengrong Zhang, Haolin Weng, Qiang eng Research Support, Non-U.S. Gov't England 2021/08/16 J Steroid Biochem Mol Biol. 2021 Oct; 213:105961. doi: 10.1016/j.jsbmb.2021.105961. Epub 2021 Aug 12"