| Title: | Transgenerational effects of prenatal bisphenol A on social recognition |
| Author(s): | Wolstenholme JT; Goldsby JA; Rissman EF; |
| Address: | "Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908" |
| DOI: | 10.1016/j.yhbeh.2013.09.007 |
| ISSN/ISBN: | 1095-6867 (Electronic) 0018-506X (Print) 0018-506X (Linking) |
| Abstract: | "Bisphenol A (BPA) is a man-made endocrine disrupting compound used to manufacture polycarbonate plastics. It is found in plastic bottles, canned food linings, thermal receipts and other commonly used items. Over 93% of people have detectable BPA levels in their urine. Epidemiological studies report correlations between BPA levels during pregnancy and activity, anxiety, and depression in children. We fed female mice control or BPA-containing diets that produced plasma BPA concentrations similar to concentrations in humans. Females were mated and at birth, pups were fostered to control dams to limit BPA exposure to gestation in the first generation. Sibling pairs were bred to the third generation with no further BPA exposure. First (F1) and third (F3) generation juveniles were tested for social recognition and in the open field. Adult F3 mice were tested for olfactory discrimination. In both generations, BPA exposed juvenile mice displayed higher levels of investigation than controls in a social recognition task. In F3 BPA exposed mice, dishabituation to a novel female was impaired. In the open field, no differences were noted in F1 mice, while in F3, BPA lineage mice were more active than controls. No impairments were detected in F3 mice, all were able to discriminate different male urine pools and urine from water. No sex differences were found in any task. These results demonstrate that BPA exposure during gestation has long lasting, transgenerational effects on social recognition and activity in mice. These findings show that BPA exposure has transgenerational actions on behavior and have implications for human neurodevelopmental behavioral disorders" |
| Keywords: | "Animals Benzhydryl Compounds/*pharmacology Endocrine Disruptors/*pharmacology Female Male Maternal Exposure Mice Mice, Inbred C57BL Motor Activity/drug effects Phenols/*pharmacology Pregnancy Prenatal Exposure Delayed Effects/*psychology Recognition, Psyc;" |
| Notes: | "MedlineWolstenholme, Jennifer T Goldsby, Jessica A Rissman, Emilie F eng F32 ES019404/ES/NIEHS NIH HHS/ R01 ES022759/ES/NIEHS NIH HHS/ R01 MH057759/MH/NIMH NIH HHS/ Research Support, N.I.H., Extramural 2013/10/09 Horm Behav. 2013 Nov; 64(5):833-9. doi: 10.1016/j.yhbeh.2013.09.007. Epub 2013 Oct 5" |
