| Title: | Urinary concentrations of PAH and VOC metabolites in marijuana users |
| Author(s): | Wei B; Alwis KU; Li Z; Wang L; Valentin-Blasini L; Sosnoff CS; Xia Y; Conway KP; Blount BC; |
| Address: | "Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States. Electronic address: bwei@cdc.gov. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States. Division of Epidemiology, Services and Prevention Research at the National Institutes of Health, United States" |
| DOI: | 10.1016/j.envint.2015.12.003 |
| ISSN/ISBN: | 1873-6750 (Electronic) 0160-4120 (Print) 0160-4120 (Linking) |
| Abstract: | "BACKGROUND: Marijuana is seeing increased therapeutic use, and is the world's third most-popular recreational drug following alcohol and tobacco. This widening use poses increased exposure to potentially toxic combustion by-products from marijuana smoke and the potential for public health concerns. OBJECTIVES: To compare urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) among self-reported recent marijuana users and nonusers, while accounting for tobacco smoke exposure. METHODS: Measurements of PAH and VOC metabolites in urine samples were combined with questionnaire data collected from participants in the National Health and Nutrition Examination Surveys (NHANES) from 2005 to 2012 in order to categorize participants (>/=18years) into exclusive recent marijuana users and nonusers. Adjusted geometric means (GMs) of urinary concentrations were computed for these groups using multiple regression analyses to adjust for potential confounders. RESULTS: Adjusted GMs of many individual monohydroxy PAHs (OH-PAHs) were significantly higher in recent marijuana users than in nonusers (p<0.05). Urinary thiocyanate (p<0.001) and urinary concentrations of many VOC metabolites, including metabolites of acrylonitrile (p<0.001) and acrylamide (p<0.001), were significantly higher in recent marijuana users than in nonusers. CONCLUSIONS: We found elevated levels of biomarkers for potentially harmful chemicals among self-identified, recent marijuana users compared with nonusers. These findings suggest that further studies are needed to evaluate the potential health risks to humans from the exposure to these agents when smoking marijuana" |
| Keywords: | Adolescent Adult Biomarkers/urine Cannabis/*adverse effects Case-Control Studies Female Humans Male Marijuana Smoking/adverse effects/*urine Middle Aged Polycyclic Aromatic Hydrocarbons/*urine Tobacco Smoke Pollution/adverse effects Volatile Organic Compo; |
| Notes: | "MedlineWei, Binnian Alwis, K Udeni Li, Zheng Wang, Lanqing Valentin-Blasini, Liza Sosnoff, Connie S Xia, Yang Conway, Kevin P Blount, Benjamin C eng CC999999/Intramural CDC HHS/ Netherlands 2015/12/23 Environ Int. 2016 Mar; 88:1-8. doi: 10.1016/j.envint.2015.12.003. Epub 2015 Dec 12" |
