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ACS Nano

Title:		Surfactant-like Peptide Self-Assembled into Hybrid Nanostructures for Electronic Nose Applications
Author(s):		Weerakkody JS; El Kazzy M; Jacquier E; Elchinger PH; Mathey R; Ling WL; Herrier C; Livache T; Buhot A; Hou Y;
Address:		"Universite Grenoble Alpes, CEA, CNRS, IRIG, SyMMES, 17 Avenue des Martyrs, Grenoble 38000, France. Universite Grenoble Alpes, CEA, CNRS, IRIG, IBS, 71 Avenue des Martyrs, Grenoble 38000, France. Aryballe, 7 Rue des Arts et Metiers, Grenoble 38000, France"
Journal Title:		ACS Nano
Year:		2022
Volume:		20220217
Issue:		3
Page Number:		4444 - 4457
DOI:		10.1021/acsnano.1c10734
ISSN/ISBN:		1936-086X (Electronic) 1936-0851 (Linking)
Abstract:		"An electronic nose (e-nose) utilizes a multisensor array, which relies on the vector contrast of combinatorial responses, to effectively discriminate between volatile organic compounds (VOCs). In recent years, hierarchical structures made of nonbiological materials have been used to achieve the required sensor diversity. With the advent of self-assembling peptides, the ability to tune nanostructuration, surprisingly, has not been exploited for sensor array diversification. In this work, a designer surfactant-like peptide sequence, CG(7)-NH(2), is used to fabricate morphologically and physicochemically heterogeneous 'biohybrid' surfaces on Au-covered chips. These multistructural sensing surfaces, containing immobilized hierarchical nanostructures surrounded by self-assembled monolayers, are used for the detection and discrimination of VOCs. Through a simple and judicious design process, involving changes in pH and water content of peptide solutions, a five-element biohybrid sensor array coupled with a gas-phase surface plasmon resonance imaging system is shown to achieve sufficient discriminatory capabilities for four VOCs. Moreover, the limit of detection of the multiarray system is bench-marked at <1 and 6 ppbv for hexanoic acid and phenol (esophago-gastric biomarkers), respectively. Finally, the humidity effects are characterized, identifying the dissociation rate constant as a robust descriptor for classification, further exemplifying their efficacy as biomaterials in the field of artificial olfaction"
Keywords:		Electronic Nose *Nanostructures Peptides *Pulmonary Surfactants Surface-Active Agents *Volatile Organic Compounds humidity self-assembled monolayers supramolecular structures surface plasmon resonance imaging surfactant-like peptide volatile organic compo;
Notes:		"MedlineWeerakkody, Jonathan S El Kazzy, Marielle Jacquier, Elise Elchinger, Pierre-Henri Mathey, Raphael Ling, Wai Li Herrier, Cyril Livache, Thierry Buhot, Arnaud Hou, Yanxia eng Research Support, Non-U.S. Gov't 2022/02/18 ACS Nano. 2022 Mar 22; 16(3):4444-4457. doi: 10.1021/acsnano.1c10734. Epub 2022 Feb 17"