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Parasit Vectors

Title:		The sex pheromone heptacosane enhances the mating competitiveness of sterile Aedes aegypti males
Author(s):		Wang LM; Li N; Zhang M; Tang Q; Lu HZ; Zhou QY; Niu JX; Xiao L; Peng ZY; Zhang C; Liu M; Wang DQ; Deng SQ;
Address:		"The Key Laboratory of Microbiology and Parasitology of Anhui Province, the Key Laboratory of Zoonoses of High Institutions in Anhui, Department of Pathogen Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China. Department of Radiotherapy, The First Affiliated Hospital of Anhui Medical University, Hefei, China. The Key Laboratory of Microbiology and Parasitology of Anhui Province, the Key Laboratory of Zoonoses of High Institutions in Anhui, Department of Pathogen Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China. iammiaoliu@126.com. Chinese Center for Disease Control and Prevention, National Institute of Parasitic Diseases, Shanghai, China. wangdq@nipd.chinacdc.cn. The Key Laboratory of Microbiology and Parasitology of Anhui Province, the Key Laboratory of Zoonoses of High Institutions in Anhui, Department of Pathogen Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China. dengshengqun@163.com"
Journal Title:		Parasit Vectors
Year:		2023
Volume:		20230315
Issue:		1
Page Number:		102 -
DOI:		10.1186/s13071-023-05711-6
ISSN/ISBN:		1756-3305 (Electronic) 1756-3305 (Linking)
Abstract:		"BACKGROUND: Aedes aegypti is a vector that transmits various viral diseases, including dengue and Zika. The radiation-based sterile insect technique (SIT) has a limited effect on mosquito control because of the difficulty in irradiating males without reducing their mating competitiveness. In this study, the insect sex pheromone heptacosane was applied to Ae. aegypti males to investigate whether it could enhance the mating competitiveness of irradiated males. METHODS: Heptacosane was smeared on the abdomens of Ae. aegypti males that were allowed to mate with untreated virgin females. The insemination rate was used to assess the attractiveness of heptacosane-treated males to females. The pupae were irradiated with different doses of X-rays and gamma-rays, and the emergence, survival time, egg number, and hatch rate were detected to find the optimal dose of X-ray and gamma-ray radiation. The males irradiated at the optimal dose were smeared with heptacosane, released in different ratios with untreated males, and mated with females. The effect of heptacosane on the mating competitiveness of irradiated mosquitoes was then evaluated by the hatch rate, induced sterility, and mating competitiveness index. RESULTS: Applying heptacosane to Ae. aegypti males significantly increased the insemination rate of females by 20%. Pupal radiation did not affect egg number but significantly reduced survival time and hatch rate. The emergence of the pupae was not affected by X-ray radiation but was affected by gamma-ray radiation. Pupae exposed to 60 Gy X-rays and 40 Gy gamma-rays were selected for subsequent experiments. After 60 Gy X-ray irradiation or 40 Gy gamma-ray irradiation, the average hatch rate was less than 0.1%, and the average survival time was more than 15 days. Moreover, at the same release ratio, the hatch rate of the irradiated group perfumed with heptacosane was lower than that of the group without heptacosane. Conversely, the male sterility and male mating competitiveness index were significantly increased due to the use of heptacosane. CONCLUSIONS: The sex pheromone heptacosane enhanced the interaction between Ae. aegypti males and females. Perfuming males irradiated by X-rays or gamma-rays with heptacosane led to a significant increase in mating competitiveness. This study provided a new idea for improving the application effect of SIT"
Keywords:		"Animals Female Humans Male *Aedes/radiation effects *Sex Attractants/pharmacology Mosquito Vectors/radiation effects *Infertility, Male Reproduction Pupa/radiation effects Sexual Behavior, Animal/radiation effects *Zika Virus *Zika Virus Infection Aedes a;"
Notes:		"MedlineWang, Lin-Min Li, Ni Zhang, Mao Tang, Qi Lu, Hong-Zheng Zhou, Qing-Ya Niu, Jia-Xuan Xiao, Liang Peng, Zhe-Yu Zhang, Chao Liu, Miao Wang, Duo-Quan Deng, Sheng-Qun eng 8210082025/National Natural Science Foundation of China/ 2108085QH347/Anhui Provincial Natural Science Foundation Project/ 2020xkj005/Research Fund Project of Anhui Medical University/ England 2023/03/17 Parasit Vectors. 2023 Mar 15; 16(1):102. doi: 10.1186/s13071-023-05711-6"