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Talanta

Title:		Quantification of a volatile deuterated compound by the differential scanning calorimetry combined with quantitative nuclear magnetic resonance and its verification by the mass balance method combined with gas chromatography-mass spectrometry
Author(s):		Wang J; Zhang W; Huang T; Su P; Yang Y;
Address:		"College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, PR China. Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, 100029, PR China. College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, PR China. Electronic address: suping@mail.buct.edu.cn. College of Chemistry, Beijing University of Chemical Technology, Beijing, 100029, PR China. Electronic address: yangyi@mail.buct.edu.cn"
Journal Title:		Talanta
Year:		2022
Volume:		20220512
Issue:
Page Number:		123538 -
DOI:		10.1016/j.talanta.2022.123538
ISSN/ISBN:		1873-3573 (Electronic) 0039-9140 (Linking)
Abstract:		"Differential scanning calorimetry (DSC) technology has been proven to be able to detect the purity of chemical reference substances, but there are few studies on its applicability to volatile organic compounds. In this study, the purity of a volatile deuterated compound (benzene-d(6)) was successfully assessed by the DSC combined with quantitative nuclear magnetic resonance (qNMR), in which the qNMR determined the content of benzene (as an isotopic impurity). The result was verified by the mass balance method combined with gas chromatography-mass spectrometry (GC-MS), in which the GC-MS determined the content of benzene. The results showed that the purity value of benzene-d(6) was 994.1 mg g(-1) +/- 4.1 mg g(-1), at the 95% confidence interval, which is equivalent to the value of 994.8 mg g(-1) +/- 1.2 mg g(-1) from the mass balance method combined with GC-MS. It was proved that the DSC combined with qNMR can be used to quantify the purity of volatile deuterated compounds. For volatile compounds without isotopic impurities, they can be directly quantified by DSC. It should be noted that volatile compounds must be fully solidified under low temperature conditions to ensure the reliability of the results"
Keywords:		"*Benzene Calorimetry, Differential Scanning Gas Chromatography-Mass Spectrometry Magnetic Resonance Spectroscopy/methods Reproducibility of Results Deuterated benzene Differential scanning calorimetry Method validation Purity assessment Quantitative nucle;"
Notes:		"MedlineWang, Jingyu Zhang, Wei Huang, Ting Su, Ping Yang, Yi eng Netherlands 2022/05/18 Talanta. 2022 Aug 15; 246:123538. doi: 10.1016/j.talanta.2022.123538. Epub 2022 May 12"