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Eur Respir J

Title:		"Pulmonary changes induced by trans,trans-2,4-decadienal, a component of cooking oil fumes"
Author(s):		Wang CK; Chang LW; Chang H; Yang CH; Tsai MH; Tsai HT; Lin P;
Address:		"National Health Research Institutes, Zhunan, Miaoli County, Taiwan"
Journal Title:		Eur Respir J
Year:		2010
Volume:		20090924
Issue:		3
Page Number:		667 - 675
DOI:		10.1183/09031936.00140508
ISSN/ISBN:		1399-3003 (Electronic) 0903-1936 (Linking)
Abstract:		"Cooking oil fumes (COF) are known to be associated with respiratory diseases and risk of lung cancer. Involvement of trans,trans-2,4-decadienal (tt-DDE), a major component in COF, is suspected. Male CD-1(R) (ICR) mice were intratracheally instilled with either 8 or 24 mg.kg(-1) tt-DDE weekly for 8 weeks. Total numbers and types of cells in bronchoalveolar lavage fluid (BALF), as well as pathological changes, and inflammatory gene modulations in the lung tissues were assessed. We demonstrated that the number of alveolar macrophages in the BALF was significantly increased in tt-DDE-exposed animals. Histologically, there was a dose-correlated increase in epithelial hyperplasia and granulomatous nodules at the bronchioloalveolar junctions (BAJ). Although both Clara and alveolar type II cells were present in the BAJ lesion, only Clara cells were actively proliferative. However, only alveolar type II cells were found in the BAJ granulomatous nodules. Enhanced accumulation of phosphorylated signal transducer and activator of transcription 3 (pSTAT3), a known pro-carcinogenic factor, was also detected in many alveolar type II cells at the BAJ lesions. As both BAJ hyperplasia and enhanced pSTAT3 accumulation are known risk factors associated with increased lung adenocarcinoma development, these findings suggest that tt-DDE may pose a risk in lung carcinogenesis"
Keywords:		"Air Pollutants/*adverse effects Aldehydes/administration & dosage/*adverse effects Animals Bronchioles/*drug effects/pathology Bronchoalveolar Lavage Fluid Dietary Fats, Unsaturated/administration & dosage/adverse effects Hyperplasia/chemically induced In;"
Notes:		"MedlineWang, C-K Chang, L W Chang, H Yang, C-H Tsai, M-H Tsai, H-T Lin, P eng Research Support, Non-U.S. Gov't England 2009/10/03 Eur Respir J. 2010 Mar; 35(3):667-75. doi: 10.1183/09031936.00140508. Epub 2009 Sep 24"