| Title: | Identification and quantification of seven volatile n-nitrosamines in cosmetics using gas chromatography/chemical ionization-mass spectrometry coupled with head space-solid phase microextraction |
| Author(s): | Choi NR; Kim YP; Ji WH; Hwang GS; Ahn YG; |
| Address: | "Department of Environmental Science and Engineering, Ewha Womans University, Seoul 120-750, South Korea. Department of Environmental Science and Engineering, Ewha Womans University, Seoul 120-750, South Korea; Department of Chemical Engineering and Materials Science, Ewha Womans University, Seoul 120-750, South Korea. Institute of Mine Reclamation Technology, Water and Soil Research and Development Team, Chungcheong 331-803, South Korea. Omics System Research Team, Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, South Korea. Omics System Research Team, Western Seoul Center, Korea Basic Science Institute, Seoul 120-140, South Korea. Electronic address: ygahn@kbsi.re.kr" |
| DOI: | 10.1016/j.talanta.2015.10.045 |
| ISSN/ISBN: | 1873-3573 (Electronic) 0039-9140 (Linking) |
| Abstract: | "An analytical method was developed for the identification and quantification of seven volatile n-nitrosamines (n-nitrosodimethylamine [NDMA], n-nitrosoethylmethylamine [NMEA], n-nitrosodiethylamine [NDEA], n-nitrosodipropylamine [NDPA], n-nitrosodibutylamine [NDBA], n-nitrosopiperidine [NPIP], and n-nitrosopyrrolidine [NPYR]) in water insoluble cream type cosmetics. It was found that the head space-solid phase microextraction (HS-SPME) was suitable for extraction, clean up, and pre-concentration of n-nitrosamines in the cream type samples so its optimal conditions were investigated. Identification and quantification of n-nitrosamines using single quadrupole gas chromatography/mass spectrometry (GC/MS) in chemical ionization (CI) mode were carried out with accurate mass measurements. Their accurate masses of protonated molecular ions were obtained within 10 mDa of the theoretical masses when sufficiently high signal was acquired from the unique calibration method using mass and isotope accuracy. For the method validation of quantification, spiking experiments were carried out to determine the linearity, recovery, and method detection limit (MDL) using three deuterated internal standards. The average recovery was 79% within 20% relative standard deviation (RSD) at the concentration of 50 ng/g. MDLs ranged from 0.46 ng/g to 36.54 ng/g, which was satisfactory for the directive limit of 50 ng/g proposed by the European Commission (EC). As a result, it was concluded that the method could be provided for the accurate mass screening, confirmation, and quantification of n-nitrosamines when applied to cosmetic inspection" |
| Keywords: | Cosmetics/*analysis Diethylnitrosamine/analysis Dimethylnitrosamine/analogs & derivatives/analysis Gas Chromatography-Mass Spectrometry/*methods Nitrosamines/*analysis Solid Phase Microextraction/*methods Volatile Organic Compounds/analysis Accurate mass; |
| Notes: | "MedlineChoi, Na Rae Kim, Yong Pyo Ji, Won Hyun Hwang, Geum-Sook Ahn, Yun Gyong eng Research Support, Non-U.S. Gov't Netherlands 2015/12/15 Talanta. 2016; 148:69-74. doi: 10.1016/j.talanta.2015.10.045. Epub 2015 Oct 23" |
