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Elife

Title:		Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic
Author(s):		Vihani A; Hu XS; Gundala S; Koyama S; Block E; Matsunami H;
Address:		"Department of Neurobiology, Neurobiology Graduate Program, Duke University Medical Center, Durham, United States. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, United States. Department of Chemistry, University at Albany, State University of New York, Albany, United States. School of Medicine, Medical Sciences, Indiana University, Bloomington, United States. Duke Institute for Brain Sciences, Duke University, Durham, United States"
Journal Title:		Elife
Year:		2020
Volume:		20201124
Issue:
Page Number:		-
DOI:		10.7554/eLife.54501
ISSN/ISBN:		2050-084X (Electronic) 2050-084X (Linking)
Abstract:		"Understanding how genes and experience work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the main olfactory epithelium, a chemosensory structure with over a thousand distinct cell types in mice. We identified a subpopulation of olfactory sensory neurons, defined by receptor expression, whose abundances were sexually dimorphic. This subpopulation of olfactory sensory neurons was over-represented in sex-separated mice and robustly responsive to sex-specific semiochemicals. Sex-combined housing led to an attenuation of the dimorphic representations. Single-cell sequencing analysis revealed an axis of activity-dependent gene expression amongst a subset of the dimorphic OSN populations. Finally, the pro-apoptotic gene Baxwas necessary to generate the dimorphic representations. Altogether, our results suggest a role of experience and activity in influencing homeostatic mechanisms to generate a robust sexually dimorphic phenotype in the main olfactory epithelium"
Keywords:		"Animal Husbandry Animals Biological Variation, Population Female Gene Expression Regulation Male Mice, Inbred C57BL Mice, Knockout *Neuronal Plasticity *Odorants Olfactory Mucosa/*innervation/metabolism Olfactory Receptor Neurons/metabolism/*physiology Ph;"
Notes:		"MedlineVihani, Aashutosh Hu, Xiaoyang Serene Gundala, Sivaji Koyama, Sachiko Block, Eric Matsunami, Hiroaki eng DC014423/DC/NIDCD NIH HHS/ DC016224/DC/NIDCD NIH HHS/ 1556207/National Science Foundation/International Comparative Study Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. England 2020/11/25 Elife. 2020 Nov 24; 9:e54501. doi: 10.7554/eLife.54501"