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Int J Mol Sci

Title:		Sex Steroids and the Shaping of the Peripubertal Brain: The Sexual-Dimorphic Set-Up of Adult Neurogenesis
Author(s):		Trova S; Bovetti S; Bonzano S; De Marchis S; Peretto P;
Address:		"Department of Life Sciences and Systems Biology (DBIOS), University of Torino, 10123 Turin, Italy. Neuroscience Institute Cavalieri Ottolenghi (NICO), Orbassano, 10043 Turin, Italy"
Journal Title:		Int J Mol Sci
Year:		2021
Volume:		20210726
Issue:		15
Page Number:		-
DOI:		10.3390/ijms22157984
ISSN/ISBN:		1422-0067 (Electronic) 1422-0067 (Linking)
Abstract:		"Steroid hormones represent an amazing class of molecules that play pleiotropic roles in vertebrates. In mammals, during postnatal development, sex steroids significantly influence the organization of sexually dimorphic neural circuits underlying behaviors critical for survival, such as the reproductive one. During the last decades, multiple studies have shown that many cortical and subcortical brain regions undergo sex steroid-dependent structural organization around puberty, a critical stage of life characterized by high sensitivity to external stimuli and a profound structural and functional remodeling of the organism. Here, we first give an overview of current data on how sex steroids shape the peripubertal brain by regulating neuroplasticity mechanisms. Then, we focus on adult neurogenesis, a striking form of persistent structural plasticity involved in the control of social behaviors and regulated by a fine-tuned integration of external and internal cues. We discuss recent data supporting that the sex steroid-dependent peripubertal organization of neural circuits involves a sexually dimorphic set-up of adult neurogenesis that in turn could be relevant for sex-specific reproductive behaviors"
Keywords:		Adult Animals Brain/*metabolism Female Gonadal Steroid Hormones/*metabolism Humans Male *Neurogenesis Puberty/*metabolism *Sex Characteristics Sexual Behavior Social Behavior adult neurogenesis gonadal hormones pheromones puberty sexual dimorphism;Neuroscience;
Notes:		"MedlineTrova, Sara Bovetti, Serena Bonzano, Sara De Marchis, Silvia Peretto, Paolo eng PERP_RILO_21_01/Ricerca Locale UNITO 2020-2021 (PP)/ Review Switzerland 2021/08/08 Int J Mol Sci. 2021 Jul 26; 22(15):7984. doi: 10.3390/ijms22157984"